Frequency and Phenotyping of Human Immunodeficiency Virus (HIV)–Specific CD8+T Cells in HIV‐Infected Children, Using Major Histocompatibility Complex Class I Peptide Tetramers
| Autor: | F. Romagné, Daniel Scott-Algara, Colette Jouanne, Florence Buseyne, Stéphane Blanche, Yves Rivière, Christine Rouzioux |
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| Rok vydání: | 2001 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte Adolescent Anti-HIV Agents Gene Products gag Gene Products pol HIV Infections Human leukocyte antigen CD8-Positive T-Lymphocytes Biology Major histocompatibility complex Immunophenotyping CD28 Antigens Antigen Antigens CD Humans Immunology and Allergy Cytotoxic T cell Lectins C-Type Lymphocyte Count Child HLA-A Antigens CD28 HLA-DR Antigens T lymphocyte Viral Load Flow Cytometry Virology Infectious Diseases Child Preschool HIV-1 biology.protein Leukocyte Common Antigens CD8 Follow-Up Studies |
| Zdroj: | The Journal of Infectious Diseases. 183:1565-1573 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | HLA-A*02 tetramers complexed to human immunodeficiency virus (HIV) Gag SLYNTVATL and HIV Pol ILKEPVHGV peptides were used to characterize HLA class I-restricted CD8(+) T cells in 41 HIV-infected children. The frequencies and the phenotype of specific circulating CD8(+) T cells were determined in whole-blood samples by means of cytometric analysis. Background staining of 13 HLA-A*02-negative patients showed that the frequency of CD8(+) T cells was |
| Databáze: | OpenAIRE |
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