Patients hospitalized with laboratory-confirmed influenza during the 2010-2011 influenza season: exploring disease severity by virus type and subtype
| Autor: | Ruth Lynfield, Shelley M. Zansky, Sandra S. Chaves, Patricia Ryan, Lyn Finelli, Ruta Sharangpani, Jean Williams, Leslie Tengelsen, Pam Daily Kirley, Kimberly Yousey-Hindes, Emily B. Hancock, Monica M. Farley, Brian Fowler, Diana Thurston, Tiffany D'Mello, Tara Cooper, Nancy M. Bennett, Deborah Aragon, William Schaffner, Ann Thomas |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Critical Care medicine.disease_cause Virus Herd immunity law.invention Pharmacotherapy Influenza A Virus H1N1 Subtype law Internal medicine Influenza prevention Severity of illness Influenza Human medicine Influenza A virus Odds Ratio Immunology and Allergy Humans Public Health Surveillance Child Aged business.industry Influenza A Virus H3N2 Subtype Infant Odds ratio Middle Aged Orthomyxoviridae Virology Intensive care unit Respiration Artificial United States Hospitalization Influenza B virus Infectious Diseases Child Preschool Female business |
| Zdroj: | The Journal of infectious diseases. 208(8) |
| ISSN: | 1537-6613 2010-2011 |
| Popis: | Background The 2010-2011 influenza season was dominated by influenza A(H3N2) virus, but influenza A(H1N1) pdm09 (pH1N1) and B viruses cocirculated. This provided an opportunity to explore within-season predictors of severity among hospitalized patients, avoiding biases associated with season-to-season differences in strain virulence, population immunity, and healthcare seeking. Methods Population-based, laboratory-confirmed influenza hospitalization surveillance data were used to examine the association between virus type/subtype and outcomes in children and adults. Multivariable analysis explored virus type/subtype, prompt antiviral treatment, medical conditions, and age as predictors for severity (intensive care unit admission or death). Results In children, pH1N1 (adjusted odds ratio [aOR], 2.19; 95% confidence interval [CI], 1.11-4.3), chronic metabolic disease (aOR, 5.23; 95% CI, 1.74-15.69), and neuromuscular disorder (aOR, 4.84; 95% CI, 2.02-11.58) were independently associated with severity. In adults, independent predictors were pH1N1 (aOR, 2.21; 95% CI, 1.66-2.94), chronic lung disease (aOR, 1.46, 95% CI, 1.12-1.89), and neuromuscular disorder (aOR, 1.68; 95% CI, 1.11-2.52).Antiviral treatment reduced the odds of severity among adults (aOR, 0.47; 95% CI, .33-.68). Conclusions During the 2010-2011 season, pH1N1 caused more severe disease than H3N2 or B in hospitalized patients. Underlying medical conditions increased severity despite virus strain. Antiviral treatment reduced severity among adults. Our findings underscore the importance of influenza prevention. |
| Databáze: | OpenAIRE |
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