Shunting in AD increases ventricular CSF protein levels
| Autor: | Jonathan Williams, Jere Douglas Fellmann, Dawn McGuire, Tom A. Saul, Gerald D. Silverberg, Joan Carvalho, Martha Mayo |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
Hematology Neurology business.industry lcsh:RC346-429 Ventricular CSF Shunting Cellular and Molecular Neuroscience Endocrinology Developmental Neuroscience Interstitial fluid Internal medicine Medicine Cognitive decline business lcsh:Neurology. Diseases of the nervous system CSF albumin Shunt (electrical) |
| Zdroj: | Cerebrospinal Fluid Research, Vol 4, Iss Suppl 1, p S5 (2007) |
| ISSN: | 1743-8454 |
| DOI: | 10.1186/1743-8454-4-s1-s5 |
| Popis: | Background Defects in CSF circulation may impair clearance of toxic metabolites (i.e. amyloid-beta peptides – Aβ), from the brain via interstitial fluid (ISF) and so contribute to pathology in Alzheimer's disease (AD). On this view, constant drainage of CSF via a low-flow ventriculo-peritoneal shunt could facilitate clearance of toxic moieties from ISF and so slow disease progression. We tested this possibility in a prospective, randomized, double-blind controlled, multi-centre trial. We have reported elsewhere that patients with active shunts showed less cognitive decline than controls. Here, we analyse the effects of shunting on CSF protein concentrations in AD patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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