Therapeutic expansion of CD4+FoxP3+ regulatory T cells limits allergic airway inflammation during pulmonary fungal infection
| Autor: | Martina Protschka, Bianca Schulze, Daniel Piehler, Gottfried Alber, Maria Eschke, Laura Heyen, Gabriele Köhler |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_treatment Colony Count Microbial Inflammation Biology Immunoglobulin E Lymphocyte Activation T-Lymphocytes Regulatory Type 2 immune response Allergic inflammation Immunomodulation 03 medical and health sciences Mice Immune system Th2 Cells T-Lymphocyte Subsets medicine Respiratory Hypersensitivity Immunology and Allergy Animals Lymphocyte Count General Immunology and Microbiology Lung Diseases Fungal FOXP3 General Medicine Interleukin 10 Disease Models Animal 030104 developmental biology Infectious Diseases Cytokine Immunology biology.protein Cryptococcus neoformans Cytokines Female medicine.symptom Inflammation Mediators |
| Zdroj: | Pathogens and disease. 74(4) |
| ISSN: | 2049-632X |
| Popis: | Allergic asthma can be frequently caused and exacerbated by sensitization to ubiquitous fungal allergens associated with pulmonary mucus production, airway hyperresponsiveness and bronchial constriction, resulting in a complex disease that is often difficult to treat. Fungal infections are frequently complicated by the development of a type 2 immune response that prevents successful elimination of the fungal pathogen. Furthermore, production of type 2 cytokines triggers allergic airway inflammation. Following intranasal infection of BALB/c mice with the fungusCryptococcus neoformans, we recently described a more pronounced type 2 immune response in the absence of regulatory T (Treg) cells. To determine whether Treg cell expansion is able to suppress type 2-related fungal allergic inflammation, we increased Treg cell numbers during pulmonaryC. neoformansinfection by administration of an interleukin (IL)-2/anti-IL-2 complex. Expansion of Treg cells resulted in reduced immunoglobulin E production and decreased allergic airway inflammation including reduced production of pulmonary mucus and type 2 cytokines as well as production of immunosuppressive cytokines such as IL-10 and transforming growth factor-β1. From our data we conclude that Treg cells and/or their suppressive mediators represent potential targets for therapeutic intervention during allergic fungal airway disease. |
| Databáze: | OpenAIRE |
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