The Association Between HbA1c and Time in Hypoglycemia During CGM and Self-Monitoring of Blood Glucose in People With Type 1 Diabetes and Multiple Daily Insulin Injections: A Randomized Clinical Trial (GOLD-4)
| Autor: | Shilan Seyed Ahmadi, Erik Schwarcz, William H. Polonsky, Klara Westman, Sofia Dahlqvist, Aldina Pivodic, Marcus Lind, Irl B. Hirsch, Tim Heise, Jarl Hellman, Magnus Wijkman, Arndís F. Ólafsdóttir, Magnus Ekelund |
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| Rok vydání: | 2020 |
| Předmět: |
Research design
Pediatrics medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Hypoglycemia law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Diabetes mellitus Blood Glucose Self-Monitoring Internal Medicine medicine 030212 general & internal medicine Advanced and Specialized Nursing Type 1 diabetes business.industry Insulin nutritional and metabolic diseases medicine.disease Crossover study business |
| Popis: | OBJECTIVE According to recent guidelines, individuals with type 1 diabetes should spend RESEARCH DESIGN AND METHODS In the GOLD randomized crossover trial, 161 individuals with type 1 diabetes treated with multiple daily insulin injections (MDI) were randomized to continuous glucose monitoring (CGM) or conventional therapy with self-monitoring of blood glucose (SMBG) and evaluated over 16 months. We estimated the association between time spent in hypoglycemia and various mean glucose and HbA1c levels. RESULTS Time spent in hypoglycemia ( CONCLUSIONS Reaching current targets for time in hypoglycemia while at the same time reaching HbA1c targets is challenging for patients with type 1 diabetes treated with MDI both with CGM and SMBG monitoring. However, CGM is associated with considerably less time in hypoglycemia than SMBG at a broad range of HbA1c levels and is crucial for patients with MDI treatment if they are to have a chance to approach hypoglycemia targets. |
| Databáze: | OpenAIRE |
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