Homochiral Metal-Organic Frameworks for Enantioselective Separations in Liquid Chromatography
| Autor: | Marina Lledós, M. Nieves Corella-Ochoa, Vanesa Lillo, Arnau Güell-Bara, Juanjo Cabezas-Giménez, Jesus B. Tapia, J. González-Cobos, Heather N. Rubin, Sofia Calero, Salvador R. G. Balestra, Melissa M. Reynolds, Neyvis Almora-Barrios, Carlos Martí-Gastaldo, José Luis Núñez-Rico, Anton Vidal-Ferran, José Ramón Galán-Mascarós, Eduardo C. Escudero-Adán |
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| Rok vydání: | 2019 |
| Předmět: |
Chromatography
Molecular Structure Chemistry Industrial scale Enantioselective synthesis Química organometàl·lica Water Stereoisomerism General Chemistry 010402 general chemistry 01 natural sciences Biochemistry High-performance liquid chromatography Catalysis 0104 chemical sciences Colloid and Surface Chemistry Molecule Water chemistry Metal-organic framework Enantiomer Chromatography High Pressure Liquid Copper Metal-Organic Frameworks |
| Zdroj: | Corella-Ochoa, M. Nieves Tapia, Jesús B. Rubin, Heather N. Lillo, Vanesa González-Cobos, Jesús Núñez-Rico, J. L. Balestra, Salvador R. G. Almora-Barrios, Neyvis Lledós, Marina Güell-Bara, Arnau Cabezas-Giménez, Juanjo Escudero-Adán, Eduardo Vidal-Ferran, Anton Calero, Sofía Reynolds, Melissa Martí Gastaldo, Carlos Galán Mascarós, José Ramón 2019 Homochiral Metal-Organic Frameworks for Enantioselective Separations in Liquid Chromatography Journal of the American Chemical Society 141 36 14306 14316 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname Journal of the American Chemical Society RECERCAT (Dipòsit de la Recerca de Catalunya) Recercat. Dipósit de la Recerca de Catalunya |
| Popis: | Selective separation of enantiomers is a substantial challenge for the pharmaceutical industry. Chromatography on chiral stationary phases is the standard method, but at a very high cost for industrial-scale purification due to the high cost of the chiral stationary phases. Typically, these materials are poorly robust, expensive to manufacture, and often too specific for a single desired substrate, lacking desirable versatility across different chiral analytes. Here, we disclose a porous, robust homochiral metal–organic framework (MOF),TAMOF-1, built from copper(II) and an affordable linker prepared from naturall-histidine.TAMOF-1has shown to be able to separate a variety of model racemic mixtures, including drugs, in a wide range of solvents of different polarity, outperforming several commercial chiral columns for HPLC separations. Although not exploited in the present article, it is worthy to mention that the preparation of this new material is scalable to the multikilogram scale, opening unprecedented possibilities for low-energy chiral separation at the industrial scale. |
| Databáze: | OpenAIRE |
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