Failure of primary breast cancer neoangiogenesis to predict pattern of distant metastasis
| Autor: | Bernardo Amadeo Leone, Francesco Schittulli, M. De Lena, Anita Mangia, G. Naccarato, A. Paradiso, Nicola Silvestris, Carlos Teodoro Vallejo, G.M. Simone, Girolamo Ranieri, G. Bevilacqua |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Lung Neoplasms Angiogenesis CD34 Antigens CD34 Bone Neoplasms Breast Neoplasms Soft Tissue Neoplasms General Biochemistry Genetics and Molecular Biology Metastasis Breast cancer Antigens CD Predictive Value of Tests Internal medicine medicine Humans Neoplasm Metastasis Aged Neoplasm Staging Ploidies Hematology Neovascularization Pathologic business.industry Liver Neoplasms General Medicine Middle Aged medicine.disease Immunohistochemistry Primary tumor Confidence interval Receptors Estrogen Multivariate Analysis Female Receptors Progesterone business |
| Zdroj: | Clinical and Experimental Medicine. 1:127-132 |
| ISSN: | 1591-8890 |
| Popis: | In the present study, the primary tumor neoangiogenesis characteristics of 81 stage IV previously untreated breast cancers with synchronous metastasis to different distant sites (10 patients with soft tissue metastases, 31 with bone metastases, and 40 with visceral metastases) were analyzed. The primary intratumor microvessel density was assessed by immunohistochemical assay on paraffin-embedded primary tumor samples, using a monoclonal anti-CD34 antibody. The mean primary intratumor microvessel density (at 400x fields) was 78 +/- 39 (SD) microvessels per field. The microvessel density was not significantly related to the main clinical/pathological features of the tumor (age, cytohistological grade, DNA ploidy, diameter, and receptor status). The percentage of tumor cases with high primary intratumor microvessel density (cut-off median value of the series 73 +/- 39 microvessels/field) did not significantly differ in patients with bone, soft tissue, or visceral metastatic disease. Analysis of clinical outcome showed a significantly shorter time to progression and overall survival for patients with visceral metastases (P0.001 and P0.0002 by log-rank, respectively). Presence of visceral metastases was confirmed to be the only independent prognostic factor related to a worse TTP (hazard risk 2.15, 95% confidence interval 1.14-4.03, P0.02) and overall survival (hazard risk 1.81, 95% confidence interval 0.98-3.35, P0.06) by multivariate analysis. In conclusion, the assessment of neoangiogenesis of primary breast cancer by CD34 expression does not provide information predictive of different distant sites of metastasis. |
| Databáze: | OpenAIRE |
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