Suppression by kampo medicines in preneoplastic mammary hyperplastic alveolar nodules of SHN virgin mice
| Autor: | Hideo Namiki, Naoka Muroi, Seiichiro Kawashima, Hideki Kudo, Shinobu Sakamoto, Hiroshi Nagasawa, Takao Mori, Satoe Suzuki, Manabu Matsuda, Masaru Tajima, Yoshie Sugiura, Kuwa K, Noriyuki Kasahara |
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| Rok vydání: | 1993 |
| Předmět: |
endocrine system
medicine.medical_specialty Pathology Ratón Kampo Mammary gland Pharmaceutical Science Thymidine Kinase Analytical Chemistry Malignant transformation Mice Mammary Glands Animal Internal medicine Drug Discovery Medicine Animals Anticarcinogen Pharmacology Sho-saiko-to Preneoplastic state Hyperplasia business.industry Organic Chemistry Mammary Neoplasms Experimental Thymidylate Synthase medicine.disease Prolactin medicine.anatomical_structure Endocrinology Complementary and alternative medicine Molecular Medicine Female business Precancerous Conditions Drugs Chinese Herbal |
| Zdroj: | Planta medica. 59(5) |
| ISSN: | 0032-0943 |
| Popis: | Sho-saiko-to (SST), Keishi-bukuryo-gan (KBG), and Shakuyaku-kanzo-to (SKT) are Japanese modified traditional Chinese herbal medicines (Kampo medicines) consisting of 7, 5, and 2 medical plants, respectively. It is known that the hyperplastic alveolar nodule (HAN) is a representative preneoplastic state in the mammary glands of mice. We examined the effects of SST, KBG, and SKT on the formation and growth of HAN in a high-mammary-tumor strain of SHN virgin mice. Oral administration of SST for 60 days beginning at 90 days of age reduced the number and area of HAN and mammary thymidylate synthetase activity with a reduction of serum prolactin level. There was little difference between the other experimental groups and the control in the formation and growth of HAN and the enzyme activities. These results indicate that SST may have a preventive effect on malignant mammary transformations. |
| Databáze: | OpenAIRE |
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