Occult donor malignancy in pancreas transplantation
| Autor: | C. Wong, Mobin Mohteshamzadeh, R. A. Sells, Phoebe M. Hold, Raman K. Dhanda |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Nephrology
Adult medicine.medical_specialty Pathology medicine.medical_treatment Pancreas transplantation Critical Care and Intensive Care Medicine Malignancy Postoperative Complications Internal medicine Neoplasms medicine Humans Transplantation Homologous Retrospective Studies business.industry Eye Neoplasms General Medicine medicine.disease Occult Nephrectomy Tissue Donors Transplantation surgical procedures operative medicine.anatomical_structure Diabetes Mellitus Type 1 Pancreatectomy Female Pancreas Transplantation business Pancreas |
| Zdroj: | Renal failure. 29(2) |
| ISSN: | 0886-022X |
| Popis: | Tumor of the pancreas allograft is extremely rare. We report a case of an occult donor malignant undifferentiated tumor arising in a pancreas allograft. A 42-year-old female with Type 1 diabetes received a macroscopically normal pancreas allograft. The donor was a 22-year-old male who died of spontaneous intracerebral hemorrhage. She underwent transplant pancreatectomy, the histology of the pancreas allograft demonstrated a tumor measuring 5 mm in diameter, and a diagnosis of malignant undifferentiated tumor was made. In a different transplant center, the recipient of the left kidney transplant from the same donor had a nephrectomy, and the recipient of the liver transplant died of metastatic disease. Microscopic examination of the liver and kidney allografts subsequently revealed histological features identical to the pancreas tumor. Tumor transmission in transplantation may occur from an organ that contains metastatic cells or, less commonly, from the transmission of an unrecognized or occult primary tumor. A report from the United Network for Organs Sharing transplant data 1997-2002 is illustrated and discussed. This case illustrates the difficulties associated with identifying donors with occult primary tumor or metastases. |
| Databáze: | OpenAIRE |
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