Novel vitamin D compounds and skin cancer prevention
| Autor: | Rebecca S. Mason, Clare Gordon-Thomson, Vivienne E. Reeve, Wannit Tongkao-on, Eric J. Song, Tan Luu, Katie M. Dixon, Vanessa B. Sequeira, Sally E. Carter |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Vitamin
Lumisterol photoimmune suppression Endocrinology Diabetes and Metabolism skin cancer prevention Review Dermatology Disease Pharmacology chemistry.chemical_compound vitamin D compounds medicine Vitamin D and neurology business.industry Bufalin 1α 25-dihydroxyvitaminD3 medicine.disease photoprotection chemistry Skin Cancer Prevention DNA damage Skin cancer bufalin vitamin D photoproducts business photocarcinogenesis |
| Zdroj: | Dermato-endocrinology |
| ISSN: | 1938-1980 |
| DOI: | 10.4161/derm.23939 |
| Popis: | As skin cancer is one of the most costly health issues in many countries, particularly in Australia, the possibility that vitamin D compounds might contribute to prevention of this disease is becoming increasingly more attractive to researchers and health communities. In this article, important epidemiologic, mechanistic and experimental data supporting the chemopreventive potential of several vitamin D-related compounds are explored. Evidence of photoprotection by the active hormone, 1α,25dihydroxyvitamin D3, as well as a derivative of an over-irradiation product, lumisterol, a fluorinated analog and bufalin, a potential vitamin D-like compound, are provided. The aim of this article is to understand how vitamin D compounds contribute to UV adaptation and potentially, skin cancer prevention. |
| Databáze: | OpenAIRE |
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