Drug-induced myoclonus: frequency, mechanisms and management
| Autor: | María de Toledo-Heras, Félix Javier Jiménez-Jiménez, Inmaculada Puertas |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Myoclonus
congenital hereditary and neonatal diseases and abnormalities Levodopa medicine.medical_specialty Neurology Drug-Related Side Effects and Adverse Reactions GABA Agents Neurological disorder Antiparkinson Agents Serotonin Agents mental disorders medicine Humans Pharmacology (medical) Adverse effect Asterixis medicine.disease Antidepressive Agents nervous system diseases Psychiatry and Mental health Anesthesia Dopamine Antagonists Neurology (clinical) Psychopharmacology Antacids medicine.symptom Psychology Bismuth medicine.drug Muscle contraction |
| Zdroj: | CNS drugs. 18(2) |
| ISSN: | 1172-7047 |
| Popis: | Myoclonus is a sudden, abrupt, brief, 'shock-like' involuntary movement caused by muscular contractions ('positive myoclonus') or a sudden brief lapse of muscle contraction in active postural muscles ('negative myoclonus' or 'asterixis'). Various disorders can cause myoclonus including neurodegenerative and systemic metabolic disorders and CNS infections. In addition, myoclonus has been described as an adverse effect of some drugs. Level II evidence is available to indicate that levodopa, cyclic antidepressants and bismuth salts can cause myoclonus, while there is less robust evidence to associate numerous other drugs with the induction of myoclonus. The pharmacological mechanisms responsible for this adverse effect are not well established, although increased serotonergic transmission may be involved in the induction of myoclonus by several drugs. Drug-induced myoclonus usually resolves after withdrawal of the offending drug, but in some cases specific treatments are needed. |
| Databáze: | OpenAIRE |
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