LncBook: a curated knowledgebase of human long non-coding RNAs
Autor: | Jiabao Cao, Zhao Li, Lina Ma, Lin Liu, Qiang Du, Vladimir B. Bajic, Zhang Zhang, Dong Zou |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
0303 health sciences 030102 biochemistry & molecular biology Disease Association Computational biology Biology Genome Genome variation 03 medical and health sciences 0302 clinical medicine 030104 developmental biology Functional annotation microRNA Genetics Database Issue Functional significance Corrigendum 030217 neurology & neurosurgery 030304 developmental biology Coding (social sciences) |
Zdroj: | Nucleic Acids Research |
ISSN: | 1362-4962 0305-1048 |
Popis: | Long non-coding RNAs (lncRNAs) have significant functions in a wide range of important biological processes. Although the number of known human lncRNAs has dramatically increased, they are poorly annotated, posing great challenges for better understanding their functional significance and elucidating their complex functioning molecular mechanisms. Here, we present LncBook (http://bigd.big.ac.cn/lncbook), a curated knowledgebase of human lncRNAs that features a comprehensive collection of human lncRNAs and systematic curation of lncRNAs by multi-omics data integration, functional annotation and disease association. In the present version, LncBook houses a large number of 270 044 lncRNAs and includes 1867 featured lncRNAs with 3762 lncRNA–function associations. It also integrates an abundance of multi-omics data from expression, methylation, genome variation and lncRNA–miRNA interaction. Also, LncBook incorporates 3772 experimentally validated lncRNA-disease associations and further identifies a total of 97 998 lncRNAs that are putatively disease-associated. Collectively, LncBook is dedicated to the integration and curation of human lncRNAs as well as their associated data and thus bears great promise to serve as a valuable knowledgebase for worldwide research communities. |
Databáze: | OpenAIRE |
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