Marginal Zinc Deficiency Alters Essential Fatty Acid Metabolism in Healthy Men
| Autor: | Jung H Suh, Sarah J Zyba, Mark Shigenaga, Christine M McDonald, Janet C King |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Fatty Acid Desaturases
Male and promotion of well-being HDL Phytic Acid oxylipins Medicine (miscellaneous) Cardiovascular LDL lipids Essential Food Sciences Animal Production HDL cholesterol phytate Humans 3.3 Nutrition and chemoprevention Metabolic and endocrine Triglycerides Nutrition Nutrition and Dietetics fatty acid desaturase Nutrition & Dietetics Fatty Acids Essential Fatty Acids zinc Cholesterol HDL zinc biofortification Biochemical Molecular and Genetic Mechanisms Cholesterol LDL Prevention of disease and conditions Lipid Metabolism Zinc Cholesterol fatty acid metabolism LDL cholesterol |
| Zdroj: | J Nutr The Journal of nutrition, vol 152, iss 3 |
| ISSN: | 0022-3166 |
| Popis: | BackgroundRice biofortification with Zinc (Zn) can improve the Zn status of rice-consuming populations. However, the metabolic impact in humans consuming Zn-biofortified rice is unknown.ObjectivesTo determine the effects of Zn-biofortified rice on lipid metabolism in normolipidemic men.MethodsThe men consumed a rice-based diet containing 6mg Zn/d and 1.5g phytate (phytate/Zn ratio=44) for 2 wk followed by a 10-mg Zn/d diet without phytate for 4 wk. An ad libitum diet supplemented with 25mg Zn/d was then fed for 3 wk. Fasting blood samples were taken at baseline and at the end of each metabolic period for measuring plasma zinc, glucose, insulin, triglyceride (TG), LDL and HDL cholesterol, fatty acids, oxylipins, and fatty acid desaturase activities. Statistical differences were assessed by linear mixed model.ResultsFatty acid desaturase (FADS) 1 activity decreased by 29.1% (P=0.007) when the 6-mg Zn/d diet was consumed for 2 wk. This change was associated with significant decreases in HDL and LDL cholesterol. The alterations in FADS1, HDL cholesterol, and TG remained unchanged when Zn intakes were increased to 10mg/d for 4 wk. Supplementation with 25mg Zn/d for 3 wk normalized these metabolic changes and significantly increased LDL cholesterol at the end of this metabolic period compared with baseline. FADS1 activity was inversely correlated with FADS2 (rmcorr = -0.52; P=0.001) and TG (rmcorr = -0.55; P=0.001) at all time points.ConclusionsA low-zinc, high-phytate rice-based diet reduced plasma HDL cholesterol concentrations and altered fatty acid profiles in healthy men within 2 wk. Consuming 10mg Zn/d without phytate for 4 wk did not improve the lipid profiles, but a 25-mg Zn/d supplement corrects these alterations in lipid metabolism within 3 wk. |
| Databáze: | OpenAIRE |
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