Neuroimmunomodulatory compound for sensitive skin care: in vitro and clinical assessment
| Autor: | Gustavo de Campos Dieamant, Samara Eberlin, Rejane Maria Werka, Maria Del Carmen Velazquez Pereda, Cecília Nogueira, Mary L.S. Queiroz |
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| Rok vydání: | 2008 |
| Předmět: |
Keratinocytes
Ultraviolet Rays Calcitonin Gene-Related Peptide Dermatology Substance P Pharmacology Administration Cutaneous Placebo Antioxidants Sensitive skin Immunoenzyme Techniques Double-Blind Method In vivo Surveys and Questionnaires Humans Medicine Opioid peptide Cells Cultured Skin Analysis of Variance Transepidermal water loss integumentary system biology Plant Extracts business.industry Carnosine beta-Endorphin Enkephalins Middle Aged Peripheral Nervous System Agents biology.organism_classification Water Loss Insensible Pathophysiology In vitro Rhodiola rosea Immunology Cytokines Rhodiola business |
| Zdroj: | Journal of Cosmetic Dermatology. 7:112-119 |
| ISSN: | 1473-2165 1473-2130 |
| DOI: | 10.1111/j.1473-2165.2008.00373.x |
| Popis: | Summary Background The pathophysiology of sensitive skin consists of an inflammatory reaction resulting from the abnormal penetration in the skin of potentially irritating substances, which occurs due to skin barrier dysfunction and changes in the production of local neuromediators. Aims The therapeutic potential of l-carnosine and Rhodiola rosea, as antioxidant and neuromodulatory, respectively, leads us to investigate the effects of the R. rosea extract/l-carnosine–associated compound (RCAC) on sensitive skin alterations. Methods A double-blind comparative study was conducted on 124 volunteers with sensitive skin, who were selected by their reactivity to stinging test. Two randomized groups of 62 each received either a formulation containing 1% of RCAC or placebo, which was applied twice a day for 28 consecutive days. One perceptibility questionnaire was applied at the onset and at the end of the treatment to evaluate the subjective response to test product. Additionally, in vitro studies were performed to investigate RCAC neuroimmunomodulatory mechanisms. Results RCAC treatment produced in vivo protective effects in skin barrier function and a positive subjective response of sensitive skin volunteers. In vitro treatment promoted the release of proopiomelanocortin peptides and restored to normal the increased levels of neuropeptides and cytokines produced by keratinocytes exposed to ultraviolet radiation. Clinical effectiveness was measured by reduction of transepidermal water loss, positive perceptions of improvements in skin dryness and skin comfort sensation, and reduction of discomfort sensation after stinging test. Conclusions The protective effect of RCAC in skin barrier function and the positive response produced in human subjects with sensitive skin could be partially explained by our in vitro results showing a significant increase in opioid peptides release, an inhibitory effect on neuropeptides production, and modulation of cytokines production by keratinocytes under ultraviolet stress. |
| Databáze: | OpenAIRE |
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