Lateralized sex differences in stress-induced dopamine release in the rat
| Autor: | Ron M. Sullivan, Jay Waldron, Marc M. Dufresne |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Dopamine Emotions Infralimbic cortex Prefrontal Cortex Amygdala Functional Laterality chemistry.chemical_compound Internal medicine Adaptation Psychological Basal ganglia Limbic System medicine Animals Genetic Predisposition to Disease Rats Long-Evans Prefrontal cortex Neurotransmitter Depressive Disorder Sex Characteristics General Neuroscience Anxiety Disorders Neurosecretory Systems Rats medicine.anatomical_structure Endocrinology chemistry Catecholamine Psychology Neuroscience Stress Psychological medicine.drug Basolateral amygdala |
| Zdroj: | NeuroReport. 20:229-232 |
| ISSN: | 0959-4965 |
| Popis: | This study examined the possibility that hemispheric differences in stress-induced brain activation vary as a function of sex. Using in-vivo voltammetry, increases in extracellular dopamine release in response to predator odour and tail pinch stress were recorded bilaterally and simultaneously in either the infralimbic cortex or basolateral amygdala. In both stress-sensitive brain regions, significant sex x hemisphere interactions were observed, with males and females showing greater dopamine activation in right-brain and left-brain structures, respectively. Cortical asymmetries in dopamine release also showed sex-specific correlations with stress-induced neuroendocrine activation. Given the intriguing human parallels, we suggest that differential cerebral lateralization may be highly relevant to the disproportionately high incidence of stress-related disorders such as depression and anxiety seen in women. |
| Databáze: | OpenAIRE |
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