Injectable Adhesive Self-Healing Multicross-Linked Double-Network Hydrogel Facilitates Full-Thickness Skin Wound Healing
| Autor: | Fernando López Lasaosa, Bo Yang, Yiyan He, Jiang Yuhang, Hongli Mao, Jingjing Wei, Jun Yang, Peng Wanjia, Jiliang Song, Zhongwei Gu, Jiajun Qin, Ming Li |
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| Rok vydání: | 2020 |
| Předmět: |
Models
Molecular Materials science Dopamine Molecular Conformation 02 engineering and technology 010402 general chemistry 01 natural sciences Micelle Cell Line Injections chemistry.chemical_compound Skin Physiological Phenomena Hyaluronic acid General Materials Science Hyaluronic Acid Micelles Wound Healing integumentary system technology industry and agriculture Adhesiveness Hydrogels Hydrogen Bonding Adhesion Poloxamer 021001 nanoscience & nanotechnology 0104 chemical sciences Kinetics chemistry Self-healing Self-healing hydrogels Adhesive 0210 nano-technology Wound healing Oxidation-Reduction Biomedical engineering |
| Zdroj: | ACS Applied Materials & Interfaces. 12:57782-57797 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.0c18948 |
| Popis: | The development of natural polymer-based hydrogels, combining outstanding injectability, self-healing, and tissue adhesion, with mechanical performance, able to facilitate full-thickness skin wound healing, remains challenging. We have developed an injectable micellar hydrogel (AF127/HA-ADH/OHA-Dop) with outstanding adhesive and self-healing properties able to accelerate full-thickness skin wound healing. Dopamine-functionalized oxidized hyaluronic acid (OHA-Dop), adipic acid dihydrazide-modified HA (HA-ADH), and aldehyde-terminated Pluronic F127 (AF127) were employed as polymer backbones. They were cross-linked in situ using Schiff base dynamic covalent bonds (AF127 micelle/HA-ADH network and HA-ADH/OHA-Dop network), hydrogen bonding, and π-π stacking interactions. The resulting multicross-linked double-network design forms a micellar hydrogel. The unique multicross-linked double-network structure endows the hydrogel with both improved injection abilities and mechanical performance while self-healing faster than single-network hydrogels. Inspired by mussel foot adhesive protein, OHA-Dop mimics the catechol groups seen in mussel proteins, endowing hydrogels with robust adhesion properties. We also demonstrate the potential of our hydrogels to accelerate full-thickness cutaneous wound closure and improve skin regeneration with reduced scarring. We anticipate that our hydrogel platform based on a novel multicross-linked double-network design will transform the future development of multifunctional wound dressings. |
| Databáze: | OpenAIRE |
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