Effect of Plastoquinone Derivative 10-(6′-Plastoquinonyl)decyltriphenylphosphonium (SkQ1) on Contents of Steroid Hormones and NO Level in Rats
| Autor: | Svetlana Demyanenko, L. V. Gutnikova, A. A. Alexandrova, V. N. Prokof'ev, Vladimir A. Chistyakov, E. V. Mashkina, V. A. Serezhenkov, N. P. Milyutina |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Hydrocortisone Plastoquinone medicine.medical_treatment Nitric Oxide Biochemistry Antioxidants Nitric oxide Steroid chemistry.chemical_compound Blood serum Nitrate Internal medicine medicine Animals Testosterone Intestinal Mucosa Rats Wistar Nitrite Lung Progesterone Estradiol General Medicine Rats Intestines Endocrinology Liver chemistry Derivative (chemistry) Hormone |
| Zdroj: | Biochemistry (Moscow). 75:1383-1387 |
| ISSN: | 1608-3040 0006-2979 |
| DOI: | 10.1134/s0006297910110106 |
| Popis: | Introduction of the plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) into male Wistar rats once a day for two weeks in doses of 25 and 250 nmol/kg led to elevation of 17β-estradiol level in blood serum by 33 and 41%, respectively. At the same time, nitrate and nitrite contents in the rat blood serum increased by 49 and 34%, respectively. ESR spectroscopy with diethyldithiocarbamateiron complex as a spin trap showed more than twofold increase in NO production in lungs, but not in blood, liver, and intestines, following the SkQ1 daily introduction at a dose of 25 nmol/kg. |
| Databáze: | OpenAIRE |
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