Coupled Solute Fluxes in Toad Skin
| Autor: | Thomas U. L. Biber, Peter F. Curran |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Physiology
Sodium Hypertonic Solutions Inorganic chemistry Biological Transport Active chemistry.chemical_element Tritium Article Ouabain Choline chemistry.chemical_compound Flux (metallurgy) medicine Animals Urea Mannitol Skin Carbon Isotopes digestive oral and skin physiology Isotopes of sodium chemistry Biophysics Tonicity Sodium Isotopes Anura Mathematics medicine.drug |
| Zdroj: | The Journal of General Physiology |
| ISSN: | 1540-7748 0022-1295 |
| DOI: | 10.1085/jgp.51.5.606 |
| Popis: | Net inward flux of mannitol across toad skin induced by making the outside solution hypertonic with urea has been investigated. No significant relation between net mannitol flux and net Na flux could be detected when both fluxes were measured simultaneously. In addition, the net mannitol flux caused by hypertonic solution was not altered by inhibition of Na transport with ouabain or by replacement of all Na in the bathing solutions by choline. The rate of net mannitol flux was dependent on the magnitude of the urea concentration difference across the skin and the direction of net flux could be reversed by reversing the direction of the urea concentration difference. These observations suggest that the mannitol transfer is the result of a coupling between the flows of urea and mannitol. |
| Databáze: | OpenAIRE |
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