Assessment of autonomic dysfunction with the COMPASS-31 and its relationship with disease activity and cardiovascular risks in patients with psoriatic arthritis
| Autor: | Halise hande Gezer, Mehmet Tuncay Duruöz, Sevtap Acer Kasman, Didem Erdem gürsoy |
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| Přispěvatelé: | Gezer H. H., Gursoy D. E., Kasman S. A., DURUÖZ M. T. |
| Rok vydání: | 2022 |
| Předmět: |
Internal Diseases
COMPASS-31 Autonomic dysfunction Immunology Pain Sağlık Bilimleri DIAGNOSIS İmmünoloji ve Romatoloji Severity of Illness Index İç Hastalıkları Clinical Medicine (MED) CLASSIFICATION Immunology and Rheumatology Rheumatology QUALITY-OF-LIFE Risk Factors Health Sciences Humans Immunology and Allergy Klinik Tıp (MED) ROMATOLOJİ Fatigue METABOLIC SYNDROME Internal Medicine Sciences HEART-RATE-VARIABILITY Klinik Tıp Arthritis Psoriatic NEUROPATHY Dahili Tıp Bilimleri CLINICAL MEDICINE Middle Aged Cardiovascular disease Tıp RHEUMATOID-ARTHRITIS SEVERITY Cross-Sectional Studies Autonomic Nervous System Diseases EXPERT PANEL Cardiovascular Diseases Heart Disease Risk Factors Psoriatic arthritis OBESITY Obesity Abdominal Quality of Life Medicine Female |
| Zdroj: | Rheumatology International. 42:1539-1548 |
| ISSN: | 1437-160X |
| DOI: | 10.1007/s00296-022-05110-7 |
| Popis: | This study aimed to evaluate the autonomic dysfunction as assessed by the Composite Autonomic Symptom Score-31 (COMPASS-31) as well as its relationship with disease activity and cardiovascular risks in patients with psoriatic arthritis (PsA). This cross-sectional observational study involved 118 PsA patients (85 females, mean age 45.6 years) and 64 healthy subjects. Cardiovascular risks were recorded including body mass index (BMI), hypertension (HT), diabetes mellitus (DM), dyslipidemia, metabolic syndrome (MetS), and 10-year Framingham Risk scores (FRS) were calculated. PsA was assessed with regard to disease activity, quality of life, and function. Autonomic dysfunction was evaluated using the COMPASS-31 consisting of six subdivisions including orthostatic, vasomotor, secretomotor, gastrointestinal, bladder, and pupillomotor functions. The mean disease duration was 63.3 months. The mean total COMPASS-31 score was significantly higher in PsA patients than in controls (24.4 vs 11.1; p < 0.001), as were all sub-domain scores. COMPASS-31 scores were significantly lower in patients with DAPSA-REM and MDA. The COMPASS-31 total score showed significant correlations with scores of pain, global assessment, fatigue, function, quality of life, DAPSA, and BASDAI (p < 0.05).The presence of HT, dyslipidemia, MetS, and abdominal obesity did not significantly affect the total COMPASS-31 and sub-domain scores, except for the secretomotor scores being significantly higher in patients with abdominal obesity and MetS (p < 0.05). COMPASS-31 scores were not significantly different across the FRS risk groups. The symptoms of autonomic dysfunction are prevalent in PsA patients. High disease activity and pain have negative effects on autonomic function, and also functional impairment, fatigue, and poor quality of life are associated with autonomic dysfunction. However, the COMPASS-31 was found to be insufficient to demonstrate a clear relationship between autonomic dysfunction and cardiovascular risk. |
| Databáze: | OpenAIRE |
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