Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
| Autor: | João Vitor de Assis, Mauro V. de Almeida, Marcus V. N. de Souza, Maria C.S. Lourenço, Felipe R. C. Vicente, Sílvia Helena Cardoso |
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| Rok vydání: | 2009 |
| Předmět: |
antimycobacterial activity
Tuberculosis Chemistry Isoniazid General Chemistry Carbohydrate Pharmacology bacterial infections and mycoses medicine.disease In vitro lcsh:Chemistry Minimum inhibitory concentration lcsh:QD1-999 carbohydrate Mycobacterium tuberculosis H37Rv medicine isoniazid analogs Antibacterial activity Rifampicin Nuclear chemistry medicine.drug |
| Zdroj: | Química Nova, Vol 32, Iss 6, Pp 1557-1560 (2009) Química Nova, Volume: 32, Issue: 6, Pages: 1557-1560, Published: 2009 Química Nova v.32 n.6 2009 Química Nova Sociedade Brasileira de Química (SBQ) instacron:SBQ |
| ISSN: | 0100-4042 |
| Popis: | A series of 13 compounds analogous of isoniazid condensed with carbohydrate was synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC90) in μg/mL. Several compounds exhibited antitubercular activity (0.31-3.12 μg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new compounds against tuberculosis. |
| Databáze: | OpenAIRE |
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