Interleukin-6 Is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study
| Autor: | Harold I. Feldman, Ali Ramezani, Jun Shoji, Steve Master, Martin G. Keane, Elsayed Z. Soliman, Ian R. Barrows, Valerie Teal, Sylvia Roas, Alan S. Go, Peter C. Yang, Richard Amdur, John W. Kusek, Raj Deo, Cynthia M. Tracy, Muredach P. Reilly, Joseph Gnanaraj, Cric Study Investigators, Dominic S. Raj, Monica Mukherjee |
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| Rok vydání: | 2015 |
| Předmět: |
Nephrology
Adult Male medicine.medical_specialty lcsh:Medicine 030204 cardiovascular system & hematology 03 medical and health sciences Electrocardiography 0302 clinical medicine Risk Factors Transforming Growth Factor beta Internal medicine Atrial Fibrillation medicine Humans 030212 general & internal medicine Risk factor Renal Insufficiency Chronic lcsh:Science Aged Multidisciplinary biology business.industry Interleukin-6 Tumor Necrosis Factor-alpha lcsh:R C-reactive protein Atrial fibrillation Odds ratio Middle Aged medicine.disease Confidence interval 3. Good health Interleukin 1 Receptor Antagonist Protein Endocrinology C-Reactive Protein Cohort Cardiology biology.protein lcsh:Q Female business Kidney disease Follow-Up Studies |
| Zdroj: | PLoS ONE, Vol 11, Iss 2, p e0148189 (2016) |
| ISSN: | 1932-6203 |
| Popis: | Atrial fibrillation (AF) is the most common sustained arrhythmia in patients with chronic kidney disease (CKD). In this study, we examined the association between inflammation and AF in 3,762 adults with CKD, enrolled in the Chronic Renal Insufficiency Cohort (CRIC) study. AF was determined at baseline by self-report and electrocardiogram (ECG). Plasma concentrations of interleukin(IL)-1, IL-1 Receptor antagonist, IL-6, tumor necrosis factor (TNF)-α, transforming growth factor-β, high sensitivity C-Reactive protein, and fibrinogen, measured at baseline. At baseline, 642 subjects had history of AF, but only 44 had AF in ECG recording. During a mean follow-up of 3.7 years, 108 subjects developed new-onset AF. There was no significant association between inflammatory biomarkers and past history of AF. After adjustment for demographic characteristics, comorbid conditions, laboratory values, echocardiographic variables, and medication use, plasma IL-6 level was significantly associated with presence of AF at baseline (Odds ratio [OR], 1.61; 95% confidence interval [CI], 1.21 to 2.14; P = 0.001) and new-onset AF (OR, 1.25; 95% CI, 1.02 to 1.53; P = 0.03). To summarize, plasma IL-6 level is an independent and consistent predictor of AF in patients with CKD. |
| Databáze: | OpenAIRE |
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