Airway microbiome is associated with respiratory functions and responses to ambient particulate matter exposure

Autor: Shunqing Xu, Zhongyang Zhang, Jingkun Jiang, Bo Zhao, Jianwei Lu, Haoxiang Cheng, Jing Yu, Lihong Fan, Yuan Shen, Long Cheng, Antonio Fabio Di Narzo, Jia Chen, Yang Zhou, Pengfei Yao, Changhui Wang, Jushan Zhang, Liping Wang, Dongbin Wang, Yuanyuan Li, Ke Hao
Rok vydání: 2019
Předmět:
Adult
Male
China
Vital capacity
Health
Toxicology and Mutagenesis
Respiratory System
Vital Capacity
0211 other engineering and technologies
02 engineering and technology
010501 environmental sciences
01 natural sciences
Article
Cohort Studies
FEV1/FVC ratio
Forced Expiratory Volume
RNA
Ribosomal
16S
medicine
Humans
Respiratory function
Microbiome
Respiratory system
Lung
Aged
0105 earth and related environmental sciences
Air Pollutants
021110 strategic
defence & security studies
COPD
Sequence Analysis
RNA
business.industry
Microbiota
Respiration
Sputum
Public Health
Environmental and Occupational Health
Environmental Exposure
General Medicine
Middle Aged
respiratory system
medicine.disease
Pollution
Respiratory Function Tests
respiratory tract diseases
Immunology
Female
Particulate Matter
medicine.symptom
business
Airway
Zdroj: Ecotoxicology and Environmental Safety. 167:269-277
ISSN: 0147-6513
Popis: BACKGROUND: Ambient particulate matter (PM) exposure has been associated with respiratory function decline in epidemiological studies. We hypothesize that a possible underlying mechanism is the perturbation of airway microbiome by PM exposure. METHODS: During October 2016 – October 2017, on two human cohorts (n = 115 in total) in Shanghai China, we systematically collected three categories of data (1) respiratory functions, (2) airway microbiome from sputum and (3) ambient PM(2.5) (PM of ≤ 2.5 micron in diameter) – level in ambient air. We investigated the impact of PM(2.5) on airway microbiome as well as the link between airway microbiome and respiratory functions using mix linear regression models. RESULTS: The respiratory function of our primary interest includes forced vital capacity (FVC) and forced expiratory volume in 1st second (FEV(1)). FEV(1)/FVC, an important respiratory function trait and key diagnosis criterion of COPD, was significantly associated with airway bacteria load (p = 0.0038); and FEV(1) was associated with airway microbiome profile (p = 0.013). Further, airway microbiome was significantly influenced by PM(2.5) exposure (p = 4.48E-11). CONCLUSIONS: To our knowledge, for the first time, we demonstrated the impact of PM(2.5) on airway microbiome, and reported the link between airway microbiome and respiratory functions. The results expand our understanding on the scope of PM(2.5) exposure’s influence on human respiratory system, and pointed to novel etiological mechanism of PM(2.5) exposure induced diseases.
Databáze: OpenAIRE
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