The hygiene hypothesis, the COVID pandemic, and consequences for the human microbiome
| Autor: | Tal Korem, B. Brett Finlay, Philippe Gros, Naama Geva-Zatorsky, Maria Gloria Dominguez-Bello, Martin J. Blaser, Frédéric Keck, Meghan B. Azad, Karen Guillemin, Eran Elinav, Katherine R. Amato, Hiutung Chu, Stanislav Dusko Ehrlich, Liping Zhao, Tamara Giles-Vernick, Mark Nichter, Tobias Rees, Hendrik N. Poinar, Melissa K. Melby, Sven Pettersson, Thomas C. G. Bosch, Margaret J. McFall-Ngai, Carolina Tropini |
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| Přispěvatelé: | University of British Columbia (UBC), Canadian Institute for Advanced Research (CIFAR), Northwestern University [Evanston], Children's Hospital Research Institute of Manitoba [Winnipeg, Canada], University of Manitoba [Winnipeg], Rutgers, The State University of New Jersey [New Brunswick] (RU), Rutgers University System (Rutgers), Kiel University, University of California [San Diego] (UC San Diego), University of California, MetaGenoPolis (MGP (US 1367)), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Weizmann Institute of Science [Rehovot, Israël], German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Technion - Israel Institute of Technology [Haifa], McGill University = Université McGill [Montréal, Canada], University of Oregon [Eugene], Laboratoire d'anthropologie sociale (LAS), École des hautes études en sciences sociales (EHESS)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS), Columbia University [New York], University of Hawai'i [Honolulu] (UH), University of Delaware [Newark], University of Arizona, Nanyang Technological University [Singapour], McMaster University [Hamilton, Ontario], Berggruen Institute [Los Angeles, California], Anthropologie et écologie de l’émergence des maladies - Anthropology and Ecology of Disease Emergence, Institut Pasteur [Paris], University of California (UC), Institut Pasteur [Paris] (IP) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
media_common.quotation_subject Physical Distancing MESH: Anti-Infective Agents microbiome Disease Biology Affect (psychology) MESH: Eating hygiene hypothesis [SHS]Humanities and Social Sciences Eating 03 medical and health sciences MESH: Infection Control 0302 clinical medicine MESH: Pregnancy Anti-Infective Agents Hygiene hypothesis Pregnancy Hygiene Environmental health Pandemic Humans MESH: COVID-19 MESH: Microbiota 030212 general & internal medicine Microbiome Aged 030304 developmental biology media_common MESH: Aged Infection Control 0303 health sciences MESH: Humans Multidisciplinary MESH: Physical Distancing Microbiota Human microbiome Infant COVID-19 MESH: Infant Biosocial theory MESH: Male 3. Good health MESH: Hygiene Hypothesis 13. Climate action Female MESH: Female |
| Zdroj: | Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (6), pp.e2010217118. ⟨10.1073/pnas.2010217118⟩ Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (6), pp.e2010217118. ⟨10.1073/pnas.2010217118⟩ |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.2010217118 |
| Popis: | International audience; The COVID-19 pandemic has the potential to affect the human microbiome in infected and uninfected individuals, having a substantial impact on human health over the long term. This pandemic intersects with a decades-long decline in microbial diversity and ancestral microbes due to hygiene, antibiotics, and urban living (the hygiene hypothesis). High-risk groups succumbing to COVID-19 include those with preexisting conditions, such as diabetes and obesity, which are also associated with microbiome abnormalities. Current pandemic control measures and practices will have broad, uneven, and potentially long-term effects for the human microbiome across the planet, given the implementation of physical separation, extensive hygiene, travel barriers, and other measures that influence overall microbial loss and inability for reinoculation. Although much remains uncertain or unknown about the virus and its consequences, implementing pandemic control practices could significantly affect the microbiome. In this Perspective, we explore many facets of COVID-19−induced societal changes and their possible effects on the microbiome, and discuss current and future challenges regarding the interplay between this pandemic and the microbiome. Recent recognition of the microbiome’s influence on human health makes it critical to consider both how the microbiome, shaped by biosocial processes, affects susceptibility to the coronavirus and, conversely, how COVID-19 disease and prevention measures may affect the microbiome. This knowledge may prove key in prevention and treatment, and long-term biological and social outcomes of this pandemic. |
| Databáze: | OpenAIRE |
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