Childhood trauma and clinical outcome in patients at ultra-high risk of transition to psychosis
| Autor: | Mark van der Gaag, Dorien H. Nieman, Sarah Durston, Lieuwe de Haan, Esther L. de Ruigh, Daniella S. van Dam, Tamar Kraan, Eva Velthorst, Patricia F. Schothorst |
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| Přispěvatelé: | Pediatric surgery, EMGO - Mental health, ANS - Amsterdam Neuroscience, Adult Psychiatry, APH - Amsterdam Public Health, Clinical Psychology, EMGO+ - Mental Health |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Psychosis Ultra-high risk Adolescent Cross-sectional study Ultra high risk Neuropsychological Tests Research Support Childhood trauma Young Adult SDG 3 - Good Health and Well-being Risk Factors medicine Journal Article Humans In patient Young adult Non-U.S. Gov't Child Biological Psychiatry Outcome Proportional Hazards Models Psychiatric Status Rating Scales Proportional hazards model Research Support Non-U.S. Gov't Adult Survivors of Child Abuse medicine.disease Psychiatry and Mental health Cross-Sectional Studies Psychotic Disorders Disease Progression Female sense organs Biological psychiatry Psychology Psychopathology Clinical psychology |
| Zdroj: | Schizophrenia Research, 169(1-3), 193-198. Elsevier Kraan, T, van Dam, D S, Velthorst, E, de Ruigh, E L, Nieman, D H, Durston, S, Schothorst, P, van der Gaag, M & de Haan, L 2015, ' Childhood trauma and clinical outcome in patients at ultra-high risk of transition to psychosis ', Schizophrenia Research, vol. 169, no. 1-3, pp. 193-198 . https://doi.org/10.1016/j.schres.2015.10.030 Schizophrenia research, 169(1-3), 193-198. Elsevier Schizophrenia Research, 169(1-3), 193. Elsevier |
| ISSN: | 1573-2509 0920-9964 |
| Popis: | Background: Although transition rates in 'ultra-high risk' (UHR) for psychosis samples are declining,many young individuals at UHR still experience attenuated positive symptoms and impaired functioning at follow-up. The present study examined the association between a history of childhood trauma and transition to psychosis, and symptomatic and functional outcome, in UHR patients. Method: Data on childhood trauma were available for 125 UHR individuals. Cox regression and linear regression analyseswere used to determine the association between childhood trauma, and clinical and functional outcome, during the 24-month follow-up. Results: Of the 125 UHR subjects 26 individuals (20.8%) transitioned to psychosis within 24 months. Childhood trauma did not predict transition to psychosis. However, at 24-month follow-up, UHR patientswith higher levels of childhood trauma had higher levels of attenuated positive symptoms (b=0.34, t=2.925, p < 0.01), general symptoms (b=0.29, t=2.707, p < 0.01) and depression (b=0.32, t=2.929, p < 0.01) and lower levels of global functioning (b = -0.33, t = -2.853, p = 0.01). Childhood trauma was not significantly associated with a differential course of symptoms over time, although in those with higher levels of childhood trauma, attenuated positive symptoms were more persistent at a trend level. Conclusions: Our results suggest that childhood trauma may contribute to a shared vulnerability for several psychopathological domains. |
| Databáze: | OpenAIRE |
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