Regioselective and Diastereoselective Dearomative Multifunctionalization of In-Situ-Activated Azaarenes: An Access to Bridged Azaheterocycles

Autor:	Xuguan Bai, Yang Zhao, Qi-Lin Wang, Miao Hongjie, Zhanwei Bu
Rok vydání:	2020
Předmět:	In situ 010405 organic chemistry Chemistry Organic Chemistry Regioselectivity Physical and Theoretical Chemistry 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences
Zdroj:	Organic Letters. 22:5068-5073
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.0c01648
Popis:	Reported herein is an unprecedented multicomponent one-pot dearomative multifunctionalization of commercially available azaarenes through an in situ activation strategy, which not only achieved the first full exploitation of the reactive sites of the azaarenes, but also accomplished the efficient synthesis of bridged hydrogenated pyridines and (iso)quinolines in a highly regioselective and diastereoselective manner. In addition, we could successfully realize the step-controlled dearomative trifunctionalization and bifunctionalization of quinolines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c010d8f633cbad0274556926a3d92f6 https://doi.org/10.1021/acs.orglett.0c01648 Zobrazit plný text záznamu