Gossypol effects on cultured normal and malignant melanocytes
| Autor: | Kunie Mah, Dinah J. Teramura, Funan Hu |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Clinical Biochemistry
Melanoma Experimental Plant Science Mitochondrion Biology chemistry.chemical_compound Mice medicine Animals Endothelium Cytotoxicity Cells Cultured Choroid Gossypol Cell Biology Membrane transport Macaca mulatta Cell biology Mitochondria Endothelial stem cell chemistry Vacuolization Mechanism of action Cell culture Melanocytes medicine.symptom Energy Metabolism Cell Division Biotechnology Developmental Biology Papio |
| Zdroj: | In vitro cellulardevelopmental biology : journal of the Tissue Culture Association. 22(10) |
| ISSN: | 0883-8364 |
| Popis: | Gossypol, a polyphenolic compound known to interfere with spermatogenesis, was found to have differential cytotoxic effects on normal and malignant melanocytes in culture. Ultrastructurally it caused marked swelling and vacuolization of mitochondria; there was an almost complete loss of cristae but the outer mitochondrial membrane was retained. The cytotoxicity seemed to be selective for actively proliferating cells, regardless of normal or malignant origin. An endothelial cell line (RF/6A) derived from the choroid-retina of the eye of a rhesus fetus was extremely sensitive to its toxic effect. The mechanism of action is still unknown. The fact that mitochondria are predominantly damaged suggests that toxicity involves a perturbation of energy metabolism and the membrane transport system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|