Bone morphogenetic protein signaling in musculoskeletal cancer
| Autor: | Panayotis N. Soucacos, Myrto Bami, Mandy Milonaki, Andreas F. Mavrogenis, Evanthia A. Mitsiokapa, Andrea Angelini, Dimitrios Stamoulis |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research animal structures Bone morphogenetic protein 8A Bone Neoplasms Bone morphogenetic protein Bioinformatics Bone morphogenetic protein 2 03 medical and health sciences 0302 clinical medicine Transforming Growth Factor beta Bone morphogenetic proteins Bone tumors Medicine Animals Humans Tissue homeostasis Cancer Muscle Neoplasms Osteosarcoma business.industry Bone morphogenetic protein 10 General Medicine Musculoskeletal Bone Morphogenetic Proteins Signal Transduction Bone morphogenetic protein 7 030104 developmental biology Bone morphogenetic protein 5 Oncology GDF6 030220 oncology & carcinogenesis embryonic structures business |
| Popis: | Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-β (TGF-β) superfamily of proteins; they were initially named after their ability to induce ectopic bone formation. Published studies have proved BMPs’ role in a variety of biological processes such as embryogenesis and patterning of body axes, and maintaining adult tissue homeostasis. Other studies have focused on BMPs properties, functions and possible involvement in skeletal diseases, including cancer. A literature search mainly paying attention to the role of BMPs in musculoskeletal tumors was performed in electronic databases. This article discusses BMPs synthesis and signaling, and summarizes their prominent roles in the skeletal system for the differentiation of osteoblasts, osteocytes and chondrocytes. The review emphasizes on the role of BMP signaling in the initiation and progression of musculoskeletal cancer. |
| Databáze: | OpenAIRE |
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