Serum Levels of Fetuin A and 8-hydroxydeoxyguanosine in Morbidly Obese Subjects
| Autor: | Serkan Teksoz, Solen Himmetoglu, Kagan Zengin, Mustafa Taskin, Tijen Yesim, Yildiz Dincer |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Very low-density lipoprotein alpha-2-HS-Glycoprotein Endocrinology Diabetes and Metabolism Morbidly obese medicine.disease_cause Mice chemistry.chemical_compound 8-hydroxydeoxyguanosine Endocrinology Insulin resistance Internal medicine Internal Medicine medicine Animals Humans Triglycerides Glycated Hemoglobin biology business.industry Cholesterol Cholesterol HDL Deoxyguanosine Cholesterol LDL General Medicine Middle Aged medicine.disease Obesity Fetuin Obesity Morbid Insulin receptor chemistry 8-Hydroxy-2'-Deoxyguanosine Case-Control Studies biology.protein Female Insulin Resistance business Body mass index Oxidative stress |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 121:505-508 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-0033-1345162 |
| Popis: | Insulin resistance is one of the feature of obesity. Fetuin A is inhibitor of insulin receptor which belongs the family of receptor tyrosine kinase. It has been observed that fetuin-null mice are resistant to diet-induced obesity and they exhibit increased insulin sensitivity. Increased production of reactive oxygen species is suggested to be associated with insulin resistance. Attacks of reactive oxygen species to DNA results in base oxidation. Among the oxidized bases, 8-hydroxydeoxyguanosine is predominant lesion with pro-mutagenic potential. In the present study; measurement of serum levels of fetuin A and 8-hydroxydeoxyguanosine in obese subjects (n=46) and healthy controls (n=22), and examination of the relations between these parameters and insulin resistance have been purposed. Blood samples were taken form morbidly obese subjects after a 12 h fasting. Serum levels of fetuin A and 8-hydroxydeoxyguanosine were measured by ELISA. Statistical analysis was performed by Mann Whitney U test and correlations were examined by Spearman correlation coefficient. Serum levels of total cholesterol, HDL, LDL, VLDL, triglycerides, free T3, free T4, fasting glucose, c-peptide and %HbA1c in the obese group were found to be different from those in the control group. Serum level of fetuin A was found to be higher, 8-hydroxydeoxyguanosine level was found to be lower in the morbid obese group than those in the control group. Fetuin A was found to be positively correlated with HOMA-IR (r:0,40, P |
| Databáze: | OpenAIRE |
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