Small-Molecule Modulation of PPARs for the Treatment of Prevalent Vascular Retinal Diseases

Autor: Adam S. Duerfeldt, Xiaozheng Dou
Rok vydání: 2020
Předmět:
Models
Molecular
0301 basic medicine
Peroxisome Proliferator-Activated Receptors
Peroxisome proliferator-activated receptor
Review
Ligands
Bioinformatics
lcsh:Chemistry
chemistry.chemical_compound
0302 clinical medicine
retinopathy of prematurity
Molecular Targeted Therapy
lcsh:QH301-705.5
Spectroscopy
chemistry.chemical_classification
Drug discovery
Retinopathy of prematurity
General Medicine
Diabetic retinopathy
Computer Science Applications
diabetic retinopathy
Disease Susceptibility
Healthcare system
Catalysis
drug discovery
Inorganic Chemistry
Structure-Activity Relationship
03 medical and health sciences
Therapeutic approach
Retinal Diseases
medicine
Animals
Humans
Vascular Diseases
Physical and Theoretical Chemistry
age-related macular degeneration
Molecular Biology
peroxisome proliferator-activated receptor
business.industry
Organic Chemistry
Retinal
Macular degeneration
medicine.disease
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
chemistry
030221 ophthalmology & optometry
business
Biomarkers
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 9251, p 9251 (2020)
ISSN: 1422-0067
DOI: 10.3390/ijms21239251
Popis: Vascular-related retinal diseases dramatically impact quality of life and create a substantial burden on the healthcare system. Age-related macular degeneration, diabetic retinopathy, and retinopathy of prematurity are leading causes of irreversible blindness. In recent years, the scientific community has made great progress in understanding the pathology of these diseases and recent discoveries have identified promising new treatment strategies. Specifically, compelling biochemical and clinical evidence is arising that small-molecule modulation of peroxisome proliferator-activated receptors (PPARs) represents a promising approach to simultaneously address many of the pathological drivers of these vascular-related retinal diseases. This has excited academic and pharmaceutical researchers towards developing new and potent PPAR ligands. This review highlights recent developments in PPAR ligand discovery and discusses the downstream effects of targeting PPARs as a therapeutic approach to treating retinal vascular diseases.
Databáze: OpenAIRE
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