Monocyte-related cytokines in acute myocardial infarction
| Autor: | Mitunori Nagano, Hideki Tashiro, Michiko Momohara, Kunihiko Yamamoto, Akira Takeshita, Hiroaki Shimokawa, Ko-hei Muramatu |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Lipopolysaccharide medicine.medical_treatment Myocardial Infarction Enzyme-Linked Immunosorbent Assay Granulocyte Monocytes Leukocyte Count chemistry.chemical_compound Internal medicine medicine Humans Macrophage Myocardial infarction Aged Whole blood Analysis of Variance business.industry Monocyte Interleukin Middle Aged medicine.disease medicine.anatomical_structure Endocrinology Cytokine chemistry Immunology Cytokines Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | American Heart Journal. 130:446-452 |
| ISSN: | 0002-8703 |
| DOI: | 10.1016/0002-8703(95)90350-x |
| Popis: | To elucidate the role of monocytes in the cytokine system in acute myocardial infarction (AMI), we examined the time courses of plasma concentrations and generation capacities of monocyte-related cytokines in 17 consecutive patients with uncomplicated AMI (from day 1 to 28) and in 10 control subjects. The concentrations of monocyte-related cytokines were measured by enzyme immunoassay with horseradish peroxidase. Cytokine generation capacity was evaluated by cytokine concentrations in the culture solution 24 hours after incubation of 0.5 ml whole blood with 5 micrograms lipopolysaccharide. Two distinct patterns of increases in the cytokine concentrations were noted: transient (plasma interleukin [IL]-6) and sustained (plasma macrophage colony-stimulating factor and generation capacities of IL-1 alpha, IL-6, granulocyte colony-stimulating factor, and tumor necrosis factor alpha). There was no significant increase in the concentrations of other cytokines. These results indicate that the concentrations of the monocyte-related cytokines dynamically change during the course of AMI, suggesting that they may contribute to the inflammatory and subsequent proliferative responses in AMI. |
| Databáze: | OpenAIRE |
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