β-Adrenergic Receptor and Insulin Resistance in the Heart
| Autor: | Hitoshi Kurose, Supachoke Mangmool, Tananat Denkaew, Warisara Parichatikanond |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
β-adrenergic receptor Sympathetic nervous system medicine.medical_specialty Heart diseases medicine.medical_treatment 030204 cardiovascular system & hematology Biochemistry Pathogenesis 03 medical and health sciences 0302 clinical medicine Insulin resistance Protein kinase A Insulin receptor substrate Internal medicine Drug Discovery medicine Receptor Pharmacology Invited Review business.industry Insulin Cardiac muscle medicine.disease 030104 developmental biology medicine.anatomical_structure Endocrinology Heart failure β-blockers Molecular Medicine G protein-coupled receptor kinase business |
| Zdroj: | Biomolecules & Therapeutics |
| ISSN: | 2005-4483 1976-9148 |
| Popis: | Insulin resistance is characterized by the reduced ability of insulin to stimulate tissue uptake and disposal of glucose including cardiac muscle. These conditions accelerate the progression of heart failure and increase cardiovascular morbidity and mortality in patients with cardiovascular diseases. It is noteworthy that some conditions of insulin resistance are characterized by up-regulation of the sympathetic nervous system, resulting in enhanced stimulation of β-adrenergic receptor (βAR). Over-stimulation of βARs leads to the development of heart failure and is associated with the pathogenesis of insulin resistance in the heart. However, pathological consequences of the cross-talk between the βAR and the insulin sensitivity and the mechanism by which βAR over-stimulation promotes insulin resistance remain unclear. This review article examines the hypothesis that βARs over-stimulation leads to induction of insulin resistance in the heart. |
| Databáze: | OpenAIRE |
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