Relation between subcortical grey matter atrophy and conversion from mild cognitive impairment to Alzheimer's disease
| Autor: | Frederik Barkhof, Nikki Dieleman, Philip Scheltens, Hugo Vrenken, Christiane Möller, Femke H. Bouwman, Hyon-Ah Yi, Wiesje M. van der Flier |
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| Přispěvatelé: | Neurology, Amsterdam Neuroscience - Neurodegeneration, Radiology and nuclear medicine, Epidemiology and Data Science, Physics and medical technology |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Caudate nucleus Hippocampus Neuropsychological Tests Nucleus accumbens Audiology Grey matter 03 medical and health sciences Sex Factors 0302 clinical medicine Alzheimer Disease Memory Image Processing Computer-Assisted medicine Humans Dementia Cognitive Dysfunction Gray Matter Aged Aged 80 and over Mini–Mental State Examination medicine.diagnostic_test Putamen Age Factors Middle Aged medicine.disease Magnetic Resonance Imaging nervous system diseases Psychiatry and Mental health 030104 developmental biology Globus pallidus medicine.anatomical_structure nervous system Disease Progression Educational Status Female Surgery Neurology (clinical) Atrophy Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurology, Neurosurgery and Psychiatry, 87(4), 425-432. BMJ Publishing Group Yi, H-A, Möller, C, Dieleman, N, Bouwman, F H, Barkhof, F, Scheltens, P, van der Flier, W M & Vrenken, H 2016, ' Relation between subcortical grey matter atrophy and conversion from mild cognitive impairment to Alzheimer's disease ', Journal of Neurology, Neurosurgery and Psychiatry, vol. 87, no. 4, pp. 425-432 . https://doi.org/10.1136/jnnp-2014-309105 |
| ISSN: | 0022-3050 |
| Popis: | Objective To investigate whether subcortical grey matter atrophy predicts progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD), and to compare subcortical volumes between AD, MCI and controls. To assess the correlation between subcortical grey matter volumes and severity of cognitive impairment. Methods We included 773 participants with three-dimensional T1-weighted MRI at 3 T, made up of 181 controls, who had subjective memory symptoms with normal cognition, 201 MCIs and 391 AD. During follow-up (2.0±0.9 years), 35 MCIs converted to AD (progressive MCI) and 160 MCIs remained stable (stable MCI). We segmented volumes of six subcortical structures of the amygdala, thalamus, caudate nucleus, putamen, globus pallidus and nucleus accumbens, and of the hippocampus, using FMRIBs integrated registration and segmentation tool. Results Analysis of variances, adjusted for sex and age, showed that all structures, except the globus pallidus, were smaller in AD than in controls. In addition, the amygdala, thalamus, putamen, nucleus accumbens and hippocampus were smaller in MCIs than in controls. Across groups, all subcortical greymatter volumes, except the globus pallidus, showed a positive correlation with cognitive function, as measured by Mini Mental State Examination (MMSE) (0.16 |
| Databáze: | OpenAIRE |
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