Direction Selectivity in the Retina Is Established Independent of Visual Experience and Cholinergic Retinal Waves
| Autor: | Marla B. Feller, Alan Litke, Anastasia Anishchenko, E. J. Chichilnisky, Martin Greschner, Justin Elstrott, Alexander Sher |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Retinal Ganglion Cells
Neuroscience(all) Motion Perception Action Potentials In Vitro Techniques Receptors Nicotinic Biology Inhibitory postsynaptic potential Retina Article MOLNEURO Mice 03 medical and health sciences 0302 clinical medicine Orientation medicine Animals Motion perception Vision Ocular 030304 developmental biology Mice Knockout 0303 health sciences Adaptation Ocular General Neuroscience Age Factors Multielectrode array Acetylcholine Retinal waves Mice Inbred C57BL medicine.anatomical_structure Animals Newborn Darkness Cholinergic CELLBIO sense organs SYSNEURO Neuroscience Photic Stimulation 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuron. 58(4):499-506 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2008.03.013 |
| Popis: | SummaryDirection selectivity in the retina requires the asymmetric wiring of inhibitory inputs onto four subtypes of On-Off direction-selective ganglion cells (DSGCs), each preferring motion in one of four cardinal directions. The primary model for the development of direction selectivity is that patterned activity plays an instructive role. Here, we use a unique, large-scale multielectrode array to demonstrate that DSGCs are present at eye opening, in mice that have been reared in darkness and in mice that lack cholinergic retinal waves. These data suggest that direction selectivity in the retina is established largely independent of patterned activity and is therefore likely to emerge as a result of complex molecular interactions. |
| Databáze: | OpenAIRE |
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