Quantitative analysis of iobitridol in an injectable preparation by 1H NMR spectroscopy
| Autor: | Elena Bossù, Gianluca Gostoli, Isabella Sestili, Anna Borioni |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
1h nmr spectroscopy
Magnetic Resonance Spectroscopy Iohexol Clinical Biochemistry Analytical chemistry Pharmaceutical Science Nuclear magnetic resonance spectroscopy Reference Standards equipment and supplies Iobitridol Sensitivity and Specificity Quantitative determination Injections Analytical Chemistry chemistry.chemical_compound chemistry Drug Discovery Quantitative analysis (chemistry) Spectroscopy Biomedical engineering |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 94:19-22 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/j.jpba.2014.01.030 |
| Popis: | Nuclear magnetic resonance spectroscopy was used for direct quantitative determination of iobitridol in an injectable formulation. The method was developed on a medium field strength magnet (400 MHz) and validation was performed by assessing specificity, accuracy, precision, linearity, stability of samples and robustness. Validation data confirm that the method is highly appropriate for direct quantification of iobitridol in the final formulation. Moreover the method has a good potential for rapid screening analyses due to straightforward experimental setup and lack of any sample pretreatment. |
| Databáze: | OpenAIRE |
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