Persistent COVID-19 Symptoms Minimally Impact the Development of SARS-CoV-2-Specific T Cell Immunity
| Autor: | Heather Friberg, Adam D. Wegman, Adam T. Waickman, Hengsheng Fang, Timothy P. Endy, Kianna Ripich, Jeffrey R. Currier, Stephen J. Thomas |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Cellular immunity 2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) T-Lymphocytes Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses New York T cells Epitopes T-Lymphocyte cellular immunity Cross Reactions Antibodies Viral Microbiology Article 03 medical and health sciences Post-Acute COVID-19 Syndrome 0302 clinical medicine Immune system Coronavirus 229E Human Virology Symptom duration T cell immunity Humans Medicine 030212 general & internal medicine Aged Aged 80 and over Immunity Cellular business.industry SARS-CoV-2 symptom duration Cross reactions virus diseases COVID-19 Middle Aged biochemical phenomena metabolism and nutrition QR1-502 030104 developmental biology Infectious Diseases Immunology Female business |
| Zdroj: | Viruses, Vol 13, Iss 916, p 916 (2021) Viruses Volume 13 Issue 5 |
| ISSN: | 1999-4915 |
| Popis: | SARS-CoV-2 represents an unprecedented public health challenge. While the majority of SARS-CoV-2-infected individuals with mild-to-moderate COVID-19 resolve their infection with few complications, some individuals experience prolonged symptoms lasting for weeks after initial diagnosis. Persistent viral infections are commonly accompanied by immunologic dysregulation, but it is unclear if persistent COVID-19 impacts the development of virus-specific cellular immunity. To this end, we analyzed SARS-CoV-2-specific cellular immunity in convalescent COVID-19 patients who experienced eight days or fewer of COVID-19 symptoms or symptoms persisting for 18 days or more. We observed that persistent COVID-19 symptoms were not associated with the development of an overtly dysregulated cellular immune response. Furthermore, we observed that reactivity against the N protein from SARS-CoV-2 correlates with the amount of reactivity against the seasonal human coronaviruses 229E and NL63. These results provide insight into the processes that regulate the development of cellular immunity against SARS-CoV-2 and related human coronaviruses. |
| Databáze: | OpenAIRE |
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