The localization of infective pre-erythrocytic forms of Plasmodium cynomolgi
| Autor: | L. H. Schmidt, Richard N. Rossan, Robert Greenland, Clara S. Genther, Kathleen F. Fisher |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
Plasmodium
Pathology medicine.medical_specialty medicine.medical_treatment Splenectomy Spleen Abdominal cavity Biology Bone Marrow medicine Animals Humans Lung Lymph node Research Public Health Environmental and Occupational Health Haplorhini General Medicine biology.organism_classification Malaria Infectious Diseases medicine.anatomical_structure Liver Parasitology Lymph Nodes Lymph Bone marrow Plasmodium cynomolgi |
| Zdroj: | Transactions of the Royal Society of Tropical Medicine and Hygiene. 58:159-163 |
| ISSN: | 0035-9203 |
| DOI: | 10.1016/0035-9203(64)90005-7 |
| Popis: | 1. 1) This report deals with preliminary efforts to localize the site(s) of development of the pre-erythrocytic forms of P. cynomolgi by use of tissue implantation techniques. Twelve infant rhesus monkeys killed 4, 5, 6, and 7 days after inoculation with massive numbers of sporozoites served as donors of liver, spleen, lymph nodes, lung, and bone marrow. Fragments of these organs were implanted into the abdominal cavities of 115 subjects of the same species. 2. 2) Positive results (development of parasitaemia) were obtained with 26 of 61 liver implants carried out 4–6 days after sporozoite inoculation. The incidence of takes was largest at 6 days, at which time the peripheral blood was still negative. None of 44 implants of spleen, lymph node, lung, or bone marrow induced infections. 3. 3) These observations add strength to earlier morphological studies which have focussed attention on the liver as the site of development of pre-erythrocytic forms of primate plasmodia. Because of technical problems not yet resolved, they should not be interpreted as excluding the possibility that such development occurs in other organs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|