Familial density of alcoholism: effects on psychophysiological responses to ethanol
| Autor: | Jaylan S. Turkkan, Dace S. Svikis, George E. Bigelow, Mary E. McCaul |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Health (social science) Psychometrics Offspring Physiology Toxicology Placebo Biochemistry Fathers Behavioral Neuroscience Heart rate medicine Humans Family Family history Risk factor Psychiatry Skin Psychomotor learning Ethanol Biological Father Electric Conductivity General Medicine Alcoholism Neurology Psychology Psychomotor Performance Psychophysiology |
| Zdroj: | Alcohol. 8:219-222 |
| ISSN: | 0741-8329 |
| DOI: | 10.1016/0741-8329(91)90870-3 |
| Popis: | Recent research findings suggest that the patterning of familial alcoholism may critically determine ethanol sensitivity and severity of alcohol-related problems in the offspring. The present study examined the effects of familial alcoholism density on psychophysiological responses to ethanol administration in college males. Subjects with a positive family history of alcoholism were classified into affected biological father only (LD-FHP) versus both father and at least one second-degree affected relative (HD-FHP), and were compared to family history negative (FHN) subjects. Subjects received 1 g/kg ethanol or placebo in a double-blind procedure. A battery of subjective, physiological and psychomotor measures were collected once prior to and four times following drink administration. HD-FHP subjects showed significantly greater subjective effects, body sway and skin conductance after alcohol ingestion than either FHN or LD-FHP subjects; in contrast, there was no difference on any measure for LD-FHP versus FHN subjects. Our findings of increased ethanol sensitivity as a function of familial density of alcoholism strongly suggest the importance of carefully defining family history characteristics in all studies examining potential markers or risk factors for alcoholism. |
| Databáze: | OpenAIRE |
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