Effects of Polysaccharides Extracted from Zhu Zi Shen (Rhizoma Panacis Majoris) on Oxidative Stress and Hemodynamics in Rats with Adriamycin-induced Chronic Heart Failure
| Autor: | Tao Chen, Xue-qin Yu, Li-Rong Deng, Yue-Qin Hu, Zi-Peng Gong |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Mean arterial pressure Hemodynamics Mitochondria Heart Rats Sprague-Dawley Magnoliopsida Random Allocation chronic congestive heart failure (CHF) Polysaccharides Internal medicine Heart rate medicine Animals cardiovascular diseases Heart metabolism Medicine(all) Heart Failure business.industry Zhu Zi Shen (Rhizoma Panacis Majoris) General Medicine medicine.disease Rats Oxidative Stress Preload Endocrinology Blood pressure Doxorubicin Heart failure Ventricular pressure business Drugs Chinese Herbal |
| Zdroj: | Journal of Traditional Chinese Medicine. 31:235-240 |
| ISSN: | 0254-6272 |
| DOI: | 10.1016/s0254-6272(11)60049-6 |
| Popis: | Objective To probe into the intervening action of polysaccharides of Zhu Zi Shen (Rhizoma Panacis Majoris) (PZZS) on oxidative stress and hemodynamics in rats with adriamycin-induced chronic congestive heart failure (CHF). Methods After SD rats were successfully modeled with adriamycin, they were randomly divided into a normal control group, a model group, a PZZS group, and a captopril group, and were administrated respectively. At the end of experiment, the hemodynamic function, whole heart weight index, and the blood CK, SOD, MDA, NO, NOS were detected; and the myocardial morphological examinations were carried out. Results Compared with the normal control group, the arterial systolic pressure (SBP), diastolic pressure (DBP), mean arterial pressure (MAP), heart rate (HR), left ventricular systolic peak (LVSP), and left ventricular pressure change rate (dp/dt max ) significantly decreased, and left ventricular end diastolic pressure (LVEDP), whole heart weight index, the blood CK, MDA, NO, NOS significantly increased in the model group. PZZS significantly improved the hemodynamic function, lowered the MDA and NO levels, and decreased the CK and NOS activities in the CHF rats. Conclusion PZZS can improve the hemodynamic function, and alleviate the oxidative stress reaction in the CHF rat. |
| Databáze: | OpenAIRE |
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