The Influence of Aging on Parathyroid Hormone-Induced Enhancement in (Ca2++Mg2+)-ATPase Activity of Rabbit Renal Basolateral Membrane
| Autor: | Shoichi Kitano, Katsuhiko Sakaguchi, T Nabata, Takuo Inoue, Tsunehito Shiraishi, Shigeto Morimoto, Yoshiyuki Miyashita, Shunji Imanaka, R Morita, Kazuhisa Taniguchi, Eio Koh, Toshio Ogihara, Kazuyuki Itoh, Keisuke Fukuo |
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| Rok vydání: | 1991 |
| Předmět: |
Aging
congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty ATPase Parathyroid hormone Stimulation Calcium-Transporting ATPases Basement Membrane Internal medicine Cyclic AMP medicine Animals Epithelial polarity Kidney biology urogenital system Reabsorption business.industry nutritional and metabolic diseases Kidney Tubules medicine.anatomical_structure Endocrinology Parathyroid Hormone biology.protein Ca(2+) Mg(2+)-ATPase Rabbits Sodium-Potassium-Exchanging ATPase Geriatrics and Gerontology Signal transduction business Ca2 mg2 atpase |
| Zdroj: | Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. 28:371-376 |
| ISSN: | 0300-9173 |
| Popis: | We studied the influence of aging on the stimulatory effect of parathyroid hormone (PTH) to (Ca2+ + Mg2+)-ATPase activity of rabbit renal basolateral membrane (BLM). Stimulated by PTH, (Ca2+ + Mg2+)-ATPase activity of BLM from aged rabbits was lower than those from young rabbits. However, the stimulatory effect of cyclic AMP (cAMP) showed no differences in terms of (Ca2+ + Mg2+)-ATPase activity in BLM from aged and young rabbits. As cAMP production in BLM caused by PTH stimulation was not measured, it is unclear whether cAMP production is different in BLM from young and aged rabbits. From these results, we concluded that in BLM from aged rabbit, the lower effect of PTH on (Ca2+ + Mg2+)-ATPase is due to lower production of cAMP or some other disorder of the PTH signal transduction mechanism. As (Ca2+ + Mg2+)-pump plays an important role in Ca2+ reabsorption in kidney, its lower activity in aged rabbit may be one reason for aberration of renal calcium handling. |
| Databáze: | OpenAIRE |
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