Influence on serum asymmetric dimethylarginine (ADMA) concentrations of human paraoxonase 1 polymorphism (Q192R) and exposure to polycyclic aromatic hydrocarbons (PAHs) in Mexican women, a gene-environment interaction

Autor: Tania Ruíz-Vera, Claudia I. Almendarez-Reyna, Sandra T. Orta-García, Iván N. Pérez-Maldonado, Ángeles C. Ochoa-Martínez
Rok vydání: 2017
Předmět:
0301 basic medicine
Health
Toxicology and Mutagenesis
010501 environmental sciences
01 natural sciences
chemistry.chemical_compound
Gene Frequency
Risk Factors
Polycyclic Aromatic Hydrocarbons
Gene–environment interaction
education.field_of_study
Pyrenes
biology
General Medicine
Pollution
PON1
Biochemistry
Cardiovascular Diseases
Creatinine
Environmental Pollutants
Female
Adult
medicine.medical_specialty
Environmental Engineering
Genotype
Population
Arginine
03 medical and health sciences
Internal medicine
medicine
Genetic predisposition
Humans
Environmental Chemistry
Genetic Predisposition to Disease
education
Mexico
Allele frequency
Alleles
0105 earth and related environmental sciences
Polymorphism
Genetic
Aryldialkylphosphatase
Public Health
Environmental and Occupational Health
Paraoxonase
Environmental Exposure
General Chemistry
030104 developmental biology
Endocrinology
chemistry
biology.protein
Gene-Environment Interaction
Asymmetric dimethylarginine
Biomarkers
Zdroj: Chemosphere. 186:770-779
ISSN: 0045-6535
DOI: 10.1016/j.chemosphere.2017.08.055
Popis: It has been demonstrated that Cardiovascular Diseases (CVD) are a consequence of the combination of genetic and environmental factors and/or the interaction between them. Therefore, the aim of this study was to evaluate the impact of polycyclic aromatic hydrocarbon (PAHs) exposure and PON1 Q192R polymorphism (genetic susceptibility) on serum asymmetric dimethylarginine (ADMA) levels in Mexican women (n = 206). Urinary 1-hydroxypyrene concentrations (1-OHP; exposure biomarker for PAHs) were quantified using a high-performance liquid chromatography technique, PON1 Q192R polymorphism was genotyped using TaqMan probes and serum ADMA concentrations were evaluated using a commercially available ELISA kit. Urinary 1-OHP levels detected in this study ranged from 0.07 to 9.37 μmol/mol of creatinine (0.13–18.0 μg/g of creatinine). Regarding allele frequency (PON1 Q192R polymorphism), the 192Q-allele frequency was 0.43 and for the 192R-allele it was 0.57. In relation to serum ADMA levels, the levels ranged from 0.06 to 1.46 μmol/L. Moreover, multiple linear regression analysis was performed and associations between urinary 1-OHP levels (β = 0.05, p = 0.002), PON1 Q192R polymorphism (β = 0.04, p = 0.003) and serum ADMA concentrations were found. Besides, an interaction (gene-environment interaction) of both independent variables (1-OHP and PON1 polymorphism) on serum ADMA levels was found (β = 0.04, p = 0.02) in the constructed multiple linear model. Therefore, according to the significance of this research, it is necessary to execute health programs to reduce cardiovascular risk in the assessed population.
Databáze: OpenAIRE
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