Pumpkin seed oil vs. minoxidil 5% topical foam for the treatment of female pattern hair loss: A randomized comparative trial

Autor:	Mohamed S Hasan, Ibrahim M Ibrahim, Mohamed L. Elsaie, Khaled I Elsabaa
Rok vydání:	2021
Předmět:	Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences Cucurbita pepo 0302 clinical medicine Animal science Cucurbita Topical foam medicine Humans Plant Oils Clinical efficacy Pumpkin Seed Oil biology business.industry food and beverages Alopecia Comparative trial medicine.disease biology.organism_classification Hair loss Minoxidil 030220 oncology & carcinogenesis Female business After treatment Hair medicine.drug
Zdroj:	Journal of Cosmetic Dermatology. 20:2867-2873
ISSN:	1473-2165 1473-2130
DOI:	10.1111/jocd.13976
Popis:	Pumpkin (Cucurbita pepo L.) is an annual climber plant, and its seeds have considerable amount of oil with nutritional and medicinal importance.The present study aimed to investigate the clinical efficacy of pumpkin seed oil (PSO) in the treatment of female pattern hair loss (FPHL) and compare its effects with minoxidil 5% foam.Patients with FPHL were randomly assigned to pumpkin seed oil (n = 30; group A) or minoxidil 5% foam (n = 30; group B) for a period of 3 months. Patients were evaluated clinically and dermoscopically at baseline, at one and half months, and at the end of the 3-month study.Among group A (pumpkin seed oil) candidates, a significant decrease was observed in hair shaft diversity before and after treatment (30.5 ± 6.2%, 24.0 ± 4.02, P .001, respectively) as well as in the vellus hairs (22.5 ± 4.9, 15.8 ± 2.2, P .001, respectively). Upright regrowing hairs significantly increased from (0.13 ± 0.5) before treatment to (0.9 ± 1.0) after treatment (P .001). In group B (minoxidil applying) candidates, a significant decrease was observed in hair shaft diversity before and after treatment (31.5 ± 6.3%, 21.3 ± 2.2, P .001, respectively) as well as in the vellus hairs (24.7 ± 6.4, 19.5 ± 5.4, P = .02, respectively). Conclusion Findings of the present trial provide evidence of a promising potential role of PSO in treating FPHL.
Databáze:	OpenAIRE
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