Supplementary Figures and Legends from Anti-PD-L1 Efficacy Can Be Enhanced by Inhibition of Myeloid-Derived Suppressor Cells with a Selective Inhibitor of PI3Kδ/γ
| Autor: | Clint Allen, Carter Van Waes, Chris Silvin, Zhong Chen, Harrison Cash, Jay Friedman, Paul E. Clavijo, Ellen C. Moore, Ruth J. Davis |
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| Rok vydání: | 2023 |
| Popis: | The supplemental figures demonstrate data supportive of the overall conclusions of this manuscript including MDSC flow cytometry gating strategy, evidence for moderate suppression of peripheral MDSC T-lymphocyte suppressive capacity after IPI-145 monotherapy, evidence that combination IPI-145 and PD-L1 mAb do not alter tumor MDSC infiltration, and results suggesting that IPI-145 alone or in combination with PD-L1 mAb does not alter the growth phenotype of poorly immunogenic MOC2 tumors. |
| Databáze: | OpenAIRE |
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