Association of mtDNA D-Loop Polymorphisms with Risk of Gastric Cancer in Chinese Population
| Autor: | Xiaodong Xie, Han-bing Xie, Hua Wu, Pei-qiang Li, Li Wei, Ke-jun Ma, Feng Gao, Yong Zhao, Tian-kang Guo |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Risk China Cancer Research Genotype DNA Mutational Analysis Single-nucleotide polymorphism Adenocarcinoma Biology DNA Mitochondrial Polymerase Chain Reaction Polymorphism Single Nucleotide Pathology and Forensic Medicine Denaturing high performance liquid chromatography Asian People Stomach Neoplasms Polymorphism (computer science) Genetic predisposition Humans Aged Aged 80 and over Genetics Homoplasmy Haplotype DNA Neoplasm General Medicine Middle Aged Prognosis Molecular biology Heteroplasmy Mitochondria Haplotypes Oncology Case-Control Studies Mutation Female |
| Zdroj: | Pathology & Oncology Research. 17:735-742 |
| ISSN: | 1532-2807 1219-4956 |
| DOI: | 10.1007/s12253-011-9378-7 |
| Popis: | The aim of present study was to evaluate the association of common polymorphisms detected in mitochondrial DNA (mtDNA) D-loop region (mononucleotide repetitive D310, single nucleotide polymorphism (SNP) D16521) with susceptibility to gastric cancer (GC) in northwestern Chinese population. A total of 180 GC patients and 218 healthy controls were investigated by using PCR- denaturing high performance liquid chromatography (DHPLC) assay. Genotype and allele distributions and haplotype construction were analyzed in case–control study. We found D310 and D16521 heteroplasmy were significantly different between GC cases and controls (p |
| Databáze: | OpenAIRE |
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