Levels of immunoreactive insulin, neurotensin, and bombesin in porcine colostrum and milk
| Autor: | Björn Weström, Ekman R, Jørgen Svendsen, L. S. Svendsen, Börje W. Karlsson |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_specialty
Swine medicine.medical_treatment Radioimmunoassay chemistry.chemical_compound Blood serum Internal medicine Medicine Animals Insulin Chromatography High Pressure Liquid Neurotensin Immunoreactive insulin business.industry Colostrum Gastroenterology Bombesin Endocrinology Milk chemistry Pediatrics Perinatology and Child Health Female business |
| Zdroj: | Journal of pediatric gastroenterology and nutrition. 6(3) |
| ISSN: | 0277-2116 |
| Popis: | High concentrations of insulin (411 +/- 214 microU/ml), neurotensin-like (265 +/- 72 pg/ml), and bombesin-like immunoreactivities (1995 +/- 288 pg/ml) were detected in porcine colostrum using radioimmunoassay, as compared to the levels found in sow blood serum at farrowing (5 microU/ml, less than 12 pg/ml, and 17 pg/ml, respectively). After 72 h of lactation, the levels of insulin and neurotensin-like immunoreactivities had decreased to 28 +/- 17 microU/ml and 89 +/- 23 pg/ml, respectively, while the bombesin-like activity remained constant. Characterization with reversed-phase high performance liquid chromatography showed that the insulin immunoreactivity eluted at the same position as the insulin standard, while the elution patterns of the neurotensin-like and bombesin-like immunoreactivities (eluted in three separate peaks) did not correspond to that of their respective standards. The biological function of the peptide hormones in colostrum/milk may be as triggers of the developmental changes taking place in the nursing neonate, especially in the gastrointestinal tract. |
| Databáze: | OpenAIRE |
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