Skeletal muscle aging – Stem cells in the spotlight
| Autor: | Saskia Steiner, Julia von Maltzahn, Hellen E Ahrens, M. Juliane Jung, Henriette Henze |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Aging Satellite Cells Skeletal Muscle Population Cell Biology Neuromuscular junction Extracellular matrix 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Muscle Skeletal education education.field_of_study Myogenesis Regeneration (biology) Skeletal muscle Extracellular Matrix Cell biology 030104 developmental biology medicine.anatomical_structure Stem cell 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Mechanisms of Ageing and Development. 189:111283 |
| ISSN: | 0047-6374 |
| DOI: | 10.1016/j.mad.2020.111283 |
| Popis: | Aging is characterized by a progressive decline in tissue and organ function often linked to a reduced stem cell functionality, a cell population important for regeneration. Skeletal muscle mass and regenerative capacity decrease with advancing age. Muscle stem cells, also termed satellite cells, are a prerequisite for regeneration of skeletal muscle. Their functionality declines with increasing age, driven by intrinsic changes and changes in the stem cell niche. Here, we discuss the current understanding how muscle stem cells are affected during aging. The aging associated alterations include among others upregulation of developmental pathways in aged muscle stem cells and changes in the extracellular matrix. |
| Databáze: | OpenAIRE |
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