Offset Analgesia and The Impact of Treatment with Oxycodone and Venlafaxine: A Placebo-Controlled, Randomized Trial in Healthy Volunteers

Autor:	Anne Estrup Olesen, Asbjørn Mohr Drewes, Dina Lelic, Thomas Dahl Nissen, Matias Nilsson, Christina Brock, Lona L. Christrup
Rok vydání:	2018
Předmět:	Male Hot Temperature Venlafaxine Toxicology Placebo Serotonergic law.invention Young Adult 03 medical and health sciences 0302 clinical medicine Double-Blind Method Randomized controlled trial 030202 anesthesiology law Humans Medicine Serotonin and Noradrenaline Reuptake Inhibitors Pain Measurement Pharmacology Opioidergic Cross-Over Studies business.industry Venlafaxine Hydrochloride Pain Perception General Medicine Analgesics Opioid Opioid Anesthesia Serotonin Analgesia business Oxycodone 030217 neurology & neurosurgery medicine.drug
Zdroj:	Olesen, A E, Nissen, T D, Nilsson, M, Lelic, D, Brock, C, Christrup, L L & Drewes, A M 2018, ' Offset Analgesia and The Impact of Treatment with Oxycodone and Venlafaxine : A Placebo-Controlled, Randomized Trial in Healthy Volunteers ', Basic and Clinical Pharmacology and Toxicology, vol. 123, no. 6, pp. 727-731 . https://doi.org/10.1111/bcpt.13078
ISSN:	1742-7835
DOI:	10.1111/bcpt.13078
Popis:	Offset analgesia (OA) is a pain-modulating mechanism described as a disproportionately large decrease in pain intensity evoked by a discrete decrease in stimulus temperature. The role of the opioidergic, serotonergic and noradrenergic systems on OA remains unclear. The aim of this study was to evaluate whether OA is modulated by an opioid (oxycodone) and a serotonin and noradrenaline reuptake inhibitor (venlafaxine) in terms of psychophysical assessments. In this randomized, double-blinded, placebo-controlled cross-over study, 20 healthy male participants (mean age: 24.6 ± 2.5 years) received 10 mg oxycodone, 37.5 mg venlafaxine or placebo twice daily for 5 days in three periods. OA was induced by noxious thermal stimulation on the forearm at baseline and last day of treatment. A control session of constant stimulus intensity was included for comparison. OA magnitude was unaffected by oxycodone and venlafaxine (p = 0.20 and p = 0.90, respectively). Oxycodone affected the control paradigm where a decreased rating of pain intensity was observed compared to placebo (p = 0.001). OA could not be modulated by oxycodone or venlafaxine and may be a robust phenomenon in healthy volunteers and not suitable for exploring pharmacological mechanisms of analgesia in human beings.
Databáze:	OpenAIRE
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