ILK over-expression in human colon cancer progression correlates with activation of β-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway
| Autor: | E Papadaki, John Varakis, Vasiliki Bravou, G Klironomos, Stavros Taraviras |
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| Rok vydání: | 2005 |
| Předmět: |
Pathology
medicine.medical_specialty Colorectal cancer Down-Regulation Protein Serine-Threonine Kinases Biology medicine.disease_cause Pathology and Forensic Medicine medicine Humans Neoplasm Invasiveness Epithelial–mesenchymal transition Phosphorylation Protein kinase B beta Catenin Neoplasm Staging Regulation of gene expression Forkhead Box Protein O1 Cadherin Forkhead Transcription Factors Cadherins medicine.disease Immunohistochemistry Neoplasm Proteins Gene Expression Regulation Neoplastic Tumor progression Lymphatic Metastasis Catenin Colonic Neoplasms embryonic structures Disease Progression Cancer research Carcinogenesis Proto-Oncogene Proteins c-akt |
| Zdroj: | The Journal of Pathology. 208:91-99 |
| ISSN: | 1096-9896 0022-3417 |
| Popis: | Integrin-linked kinase (ILK) has been implicated in the development and progression of several human malignancies. However, the role of ILK in human colon cancer progression is not well established, neither have its possible in vivo downstream effectors in the disease been identified. We studied, by immunohistochemistry, ILK, beta-catenin, E-cadherin, p-Akt and p-FKHR protein expression in 125 primary colon carcinomas and 45 corresponding lymph node metastases. ILK was expressed in 98.4% of the primary tumours and in 100% of metastatic lesions. The levels of ILK expression correlated strongly with tumour invasion, tumour grade and stage and were significantly higher in metastatic tumours. Activation of beta-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway correlated significantly with both ILK expression and tumour progression parameters. In conclusion, our results suggest that ILK may have an important role in progression of human colon cancer, possibly through in vivo regulation of beta-catenin, E-cadherin and Akt pathways. Our study also provides some evidence implicating p-FKHR in human colon carcinogenesis and ILK signalling. |
| Databáze: | OpenAIRE |
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