Preparation of Reductant-Responsive N-Maleoyl-Functional Chitosan/Poly(vinyl alcohol) Nanofibers for Drug Delivery
| Autor: | Szu-Chieh Huang, Chih-Kuang Chen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Vinyl alcohol
Polymers Nanofibers Pharmaceutical Science Context (language use) Biocompatible Materials 02 engineering and technology 010402 general chemistry 01 natural sciences Chitosan chemistry.chemical_compound Mice Drug Delivery Systems Drug Discovery Polymer chemistry Cell Adhesion Animals Spinning Cells Cultured Cell Proliferation Skin Wound Healing integumentary system Bacteria Fibroblasts 021001 nanoscience & nanotechnology Bandages Electrospinning 0104 chemical sciences Anti-Bacterial Agents Solvent Chemical engineering chemistry Reducing Agents Nanofiber Polyvinyl Alcohol Drug delivery Molecular Medicine 0210 nano-technology |
| Zdroj: | Molecular pharmaceutics. 13(12) |
| ISSN: | 1543-8392 |
| Popis: | Chitosan/poly(vinyl alcohol) (CS/PVA) hybrid nanofibers via electrospinning have been extensively used as wound dressing materials. However, there are still several drawbacks associated with their processing procedures and material properties, including the necessity of using acid solutions as spinning solvents, the need of employing highly toxic cross-linkers, and the lack of stimuli-responsive functions. In this context, water-soluble N-maleoyl functional chitosan (MCS) was successfully synthesized and well characterized. Using neutral deionized water as a spinning solvent, MCS/PVA nanofibers were prepared via electrospinning under the optimal operating conditions. Instead of using conventional cross-linking methodologies, the MCS/PVA nanofibers were further cross-linked by UV-irradiation with allyl disulfide as a cross-linker. The resulting disulfide cross-linked MCS/PVA (ss-MCS/PVA) nanofibers have demonstrated great water stability, high water regain ability, insignificant cytotoxicity, and reductant-responsive functions. With a successful loading of an antibiotic tetracycline hydrochloride (TCH) and those favorable material features, ss-MCS/PVA nanofibers are capable of being exploited as a potential wound dressing to promote the healing of various types of wounds. |
| Databáze: | OpenAIRE |
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