Intake of Red Wine in Different Meals Modulates Oxidized LDL Level, Oxidative and Inflammatory Gene Expression in Healthy People: A Randomized Crossover Trial
| Autor: | Alberto Carraro, Laura Di Renzo, L Iacopino, Roberto Valente, Antonino De Lorenzo, C Colica |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
GPX1
Aging Antioxidant Mediterranean diet medicine.medical_treatment Wine Mediterranean Diet Mediterranean Biochemistry Sirtuin 2 Glutathione Peroxidase GPX1 Medicine Settore MED/49 - Scienze Tecniche Dietetiche Applicate Chemokine CCL5 chemistry.chemical_classification Meal Cross-Over Studies lcsh:Cytology Glutathione peroxidase digestive oral and skin physiology General Medicine Middle Aged Catalase Up-Regulation Lipoproteins LDL Adolescent Adult Aged Down-Regulation Drinking Glutathione Peroxidase Humans Superoxide Dismutase Young Adult Cell Biology medicine.medical_specialty Article Subject Lipoproteins SOD2 LDL Internal medicine lcsh:QH573-671 business.industry Crossover study Diet Endocrinology chemistry Clinical Study business |
| Zdroj: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2014 (2014) |
| ISSN: | 1942-0994 1942-0900 |
| Popis: | Several studies have found that adherence to the Mediterranean Diet, including consumption of red wine, is associated with beneficial effects on oxidative and inflammatory conditions. We evaluate the outcome of consumption of a McDonald’s Meal (McD) and a Mediterranean Meal (MM), with and without the additive effect of red wine, in order to ascertain whether the addition of the latter has a positive impact on oxidized (ox-) LDL and on expression of oxidative and inflammatory genes. A total of 24 subjects were analyzed for ox-LDL, CAT, GPX1, SOD2, SIRT2, and CCL5 gene expression levels, before and after consumption of the 4 different meal combinations with washout intervals between each meal. When red wine is associated with McD or MM, values of ox-LDL are lowered (P<0.05) and expression of antioxidant genes is increased, while CCL5 expression is decreased (P<0.05). SIRT2 expression after MM and fasting with red wine is significantly correlated with downregulation of CCL5 and upregulation of CAT (P<0.001). GPX1 increased significantly in the comparison between baseline and all conditions with red wine. We highlighted for the first time the positive effect of red wine intake combined with different but widely consumed meal types on ox-LDL and gene expression.Trial Registration. This trial is registered with ClinicalTrials.govNCT01890070. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text