Control of myopia using orthokeratology lenses in Scandinavian children aged 6 to 12 years. Eighteen-month data from the Danish Randomized Study:Clinical study Of Near-sightedness; TReatment with Orthokeratology Lenses (CONTROL study)
| Autor: | Trine Møldrup Jakobsen, Flemming Møller |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
safety
Male medicine.medical_specialty progression rate genetic structures Contact Lenses Visual Acuity/physiology medicine.medical_treatment myopia control Denmark Population Visual Acuity orthokeratology lenses Astigmatism dropout law.invention Randomized controlled trial law Ophthalmology Myopia/therapy Myopia Medicine Humans myopia Adverse effect education Child Orthokeratologic Procedures/methods education.field_of_study business.industry Orthokeratology General Medicine medicine.disease eye diseases Confidence interval Clinical trial Contact lens randomized Contact Lenses/classification Female business Orthokeratologic Procedures |
| Zdroj: | Jakobsen, T M & Møller, F 2022, ' Control of myopia using orthokeratology lenses in Scandinavian children aged 6 to 12 years. Eighteen-month data from the Danish Randomized Study : Clinical study Of Near-sightedness; TReatment with Orthokeratology Lenses (CONTROL study) ', ACTA Ophthalmologica, vol. 100, no. 2, pp. 175-182 . https://doi.org/10.1111/aos.14911 |
| DOI: | 10.1111/aos.14911 |
| Popis: | Purpose: To investigate the efficacy of myopia control defined by axial elongation and safety of orthokeratology lenses (OKL) in a Scandinavian (Danish) population. Methods: Sixty Danish children aged 6–12 years with myopia ranging from 0.5 to 4.75 dioptres (D) spherical component and refractive astigmatism ≤2.5 D in both eyes were randomly assigned to either OKL or single-vision spectacles (SVS). Study duration was 18 months. Outcome measures were axial length (AL) measured with Lenstar LS900 (Haag-Streit, Koeniz, Switzerland) and adverse events graded with Efron Grading Scale for Contact Lens Complications. Results: Nineteen participants completed the 18-month follow-up in the OKL group and 28 in the SVS group. The average AL elongation in the OKL group was 0.24 mm smaller as compared to the SVS group (95% confidence interval 0.12–0.36, mixed model adjusted for baseline sex, age and AL). There were no fast progressors (>0.75 D/year) in the OKL group during the follow-up period in contrast to 22% in the SVS group. No treatment-requiring or vision-threatening adverse events were observed. Conclusion: Orthokeratology lenses reduced AL elongation in myopic Scandinavian children by 59%, with no treatment-requiring or vision-threatening adverse events. The results align with outcomes of previous clinical trials. |
| Databáze: | OpenAIRE |
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